Genome-wide scan to detect quantitative trait loci for milk urea nitrogen in Dutch Holstein-Friesian cows

Journal of Dairy Science
A C BouwmanJ A M van Arendonk

Abstract

Studies have reported genetic variation in milk urea nitrogen (MUN) between cows, suggesting genetic differences in nitrogen efficiency between cows. In this paper, the results of a genome-wide scan to identify quantitative trait loci (QTL) that contribute to genetic variation in MUN and MUN yield are presented. Two to 3 morning milk samples were taken from 1,926 cows, resulting in 5,502 test-day records. Test-day records were corrected for systematic environmental effects using a repeatability animal model. Averages of corrected phenotypes of 849 cows, belonging to 7 sire families, were used in an across-family multimarker regression approach to detect QTL. Animals were successfully genotyped for 1,341 single nucleotide polymorphisms. The QTL analysis resulted in 4 chromosomal regions with suggestive QTL: Bos taurus autosomes (BTA) 1, 6, 21, and 23. On BTA 1, 2 suggestive QTL affecting MUN were detected at 60 and 140 cM. On BTA 6, 1 suggestive QTL affecting both MUN and MUN yield was detected at 103 cM. On BTA 21, 1 suggestive QTL affecting MUN yield was detected at 83 cM. On BTA 23, 1 suggestive QTL affecting MUN was detected at 54 cM. Quantitative trait loci for MUN and MUN yield were suggestive and each explained between 2 ...Continue Reading

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Citations

Jan 2, 2010·Genetics, Selection, Evolution : GSE·Dorian J GarrickRohan L Fernando
Jun 6, 2015·PloS One·Brian W Kirkpatrick, Chris A Morris
Dec 10, 2013·Journal of Dairy Science·Aniek C BouwmanHenk Bovenhuis
Oct 21, 2009·Journal of Dairy Science·R M DemeterJ A M van Arendonk
Jul 27, 2011·Journal of Dairy Science·M J M RuttenJ A M van Arendonk
May 13, 2014·Tropical Animal Health and Production·Takula TshumaDirk Cornelius Lourens

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