Genome-Wide Screening Identifies Prognostic Long Noncoding RNAs in Hepatocellular Carcinoma.

BioMed Research International
Yujie FengChuandong Sun

Abstract

Hepatocellular carcinoma (HCC) is a common malignancy with a poor prognosis. Therefore, there is an urgent call for the investigation of novel biomarkers in HCC. In the present study, we identified 6 upregulated lncRNAs in HCC, including LINC01134, RHPN1-AS1, NRAV, CMB9-22P13.1, MKLN1-AS, and MAPKAPK5-AS1. Higher expression of these lncRNAs was correlated to a more advanced cancer stage and a poorer prognosis in HCC patients. Enrichment analysis revealed that these lncRNAs played a crucial role in HCC progression, possibly through a series of cancer-related biological processes, such as cell cycle, DNA replication, histone acetyltransferase complex, fatty acid oxidation, and lipid modification. Moreover, competing endogenous RNA (ceRNA) network analysis revealed that these lncRNAs could bind to certain miRNAs to promote HCC progression. Loss-of-function assays indicated that silencing of RHPN1-AS1 significantly suppressed HCC proliferation and migration. Though further validations are still needed, these identified lncRNAs could serve as valuable potential biomarkers for HCC prognosis.

References

Nov 19, 2011·Cancer Discovery·John R Prensner, Arul M Chinnaiyan
May 13, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sheng-xian YuanWei-ping Zhou
Aug 4, 2015·Carcinogenesis·Hanqing ZhuTong Wu
Mar 11, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hao ZhangChengyi Sun
Jan 27, 2017·International Journal of Molecular Sciences·Linna LuXianqun Fan
Feb 15, 2017·Nature Communications·Yang YangZhi John Lu
Nov 25, 2017·Journal of Experimental & Clinical Cancer Research : CR·Xin YinZheng-Gang Ren
Nov 20, 2018·Journal of Proteome Research·Nadezhda T DonchevaLars J Jensen
Nov 21, 2018·Contemporary Oncology Współczesna Onkologia·Prashanth RawlaJeffrey Pradeep Raj
Mar 1, 2019·Nature·Ying JiangUNKNOWN Chinese Human Proteome Project (CNHPP) Consortium
Mar 14, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yun-Long WangShi-Mei Zhuang
Apr 16, 2019·FEBS Open Bio·Fangkun LuanLigen Mo
Jul 25, 2019·The EMBO Journal·Yanying WangZusen Fan
Dec 5, 2019·European Review for Medical and Pharmacological Sciences·W-G Liu, Q Xu
Apr 11, 2020·Journal of Experimental & Clinical Cancer Research : CR·Zhonghou RongWenmao Geng
Feb 19, 2021·Journal of Experimental & Clinical Cancer Research : CR·Liang WangQingguang Liu

❮ Previous
Next ❯

Software Mentioned

GraphPad Prism
Cytoscape
ClueGO
GEPIA
R limma
GraphPad

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.