Genome-wide screening of functional long noncoding RNAs in the epicardial adipose tissues of atrial fibrillation

Biochimica Et Biophysica Acta. Molecular Basis of Disease
Xin ShiYangyang Zhang

Abstract

Atrial fibrillation (AF) is the most common arrhythmias, and patients with AF are facing increased risk of heart failure and ischemic stroke. However, the AF pathogenesis, especially the long noncoding RNAs (lncRNA)-related mechanism, has not been fully understood. In this study, we collected RNA sequencing data of the epicardial adipose tissues (EAT) from 6 AF and 6 sinus rhythm (SR) to identify the differentially expressed protein-coding genes (PCGs) and lncRNAs. Functionally, the differentially expressed PCGs were significantly enriched in bone development disease, chronic kidney failure, and kidney disease. Particularly, we found that homeobox (HOX) genes, especially the antisense RNAs, HOTAIRM1, HOXA-AS2 and HOXB-AS2, were significantly downregulated in EAT of AF. The biological function predictions for the dysregulated lncRNAs revealed that TNF signaling pathway was the most frequent pathway that the lncRNAs might participate in. In addition, SNHG16 and RP11-471B22.2 might participate in TGF-beta signaling and ECM-receptor interaction by interacting with the proteins involved in the pathways, respectively. Collectively, we provided some potentially pathogenic lncRNAs in AF, which might be useful for the related researcher...Continue Reading

Citations

Sep 25, 2020·Journal of Cellular and Molecular Medicine·Yexian FangMingming Zhang
Aug 14, 2020·International Journal of Molecular Sciences·Estefanía Lozano-VelascoHouria Daimi
Jul 2, 2021·BioMed Research International·Lifen LiaoJun Guo
Jul 22, 2021·Journal of Developmental Biology·Elena L Novikova, Milana A Kulakova
Jul 27, 2021·Experimental and Therapeutic Medicine·Wen-Bin LiuFu-Jiang Zhang

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