Genome-wide search for breast cancer linkage in large Icelandic non-BRCA1/2 families.

Breast Cancer Research : BCR
Adalgeir ArasonRosa B Barkardottir

Abstract

A significant proportion of high-risk breast cancer families are not explained by mutations in known genes. Recent genome-wide searches (GWS) have not revealed any single major locus reminiscent of BRCA1 and BRCA2, indicating that still unidentified genes may explain relatively few families each or interact in a way obscure to linkage analyses. This has drawn attention to possible benefits of studying populations where genetic heterogeneity might be reduced. We thus performed a GWS for linkage on nine Icelandic multiple-case non-BRCA1/2 families of desirable size for mapping highly penetrant loci. To follow up suggestive loci, an additional 13 families from other Nordic countries were genotyped for selected markers. GWS was performed using 811 microsatellite markers providing about five centiMorgan (cM) resolution. Multipoint logarithm of odds (LOD) scores were calculated using parametric and nonparametric methods. For selected markers and cases, tumour tissue was compared to normal tissue to look for allelic loss indicative of a tumour suppressor gene. The three highest signals were located at chromosomes 6q, 2p and 14q. One family contributed suggestive LOD scores (LOD 2.63 to 3.03, dominant model) at all these regions, witho...Continue Reading

References

Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Apr 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·A G Knudson
Nov 5, 1997·American Journal of Human Genetics·A Kong, N J Cox
Jun 8, 1999·Journal of the National Cancer Institute·J PetoM R Stratton
Aug 16, 2000·Proceedings of the National Academy of Sciences of the United States of America·T KainuH Nevanlinna
Dec 4, 2001·Nature Genetics·Gonçalo R AbecasisLon R Cardon
Jun 8, 2002·Nature Genetics·Augustine KongKari Stefansson
Oct 16, 2003·European Journal of Human Genetics : EJHG·Pia HuuskoOlli-P Kallioniemi
Sep 24, 2004·British Journal of Cancer·A C AntoniouD F Easton
Apr 1, 2006·Genes, Chromosomes & Cancer·Paula SmithMichael R Stratton
Jul 19, 2006·Genes, Chromosomes & Cancer·Laura T SmithCarl Morrison
Jul 28, 2006·Cold Spring Harbor Symposia on Quantitative Biology·B A J PonderP D P Pharoah
Nov 9, 2007·Genome Research·Tara C MatiseSteven Buyske
Dec 29, 2007·Nature Genetics·Michael R Stratton, Nazneen Rahman
Jan 17, 2009·American Journal of Human Genetics·Juan Manuel Rosa-RosaJavier Benítez
Feb 12, 2009·Breast Cancer Research and Treatment·Juan Manuel Rosa-RosaJavier Benitez
Jul 1, 2011·Journal of Cancer Research and Clinical Oncology·Bhumsuk KeamYung-Jue Bang

❮ Previous
Next ❯

Citations

Dec 23, 2011·Breast Cancer Research : BCR·Celia M T GreenwoodJohanna M Rommens
Aug 19, 2016·British Journal of Cancer·Jon G JonassonLaufey Tryggvadóttir
Nov 5, 2014·Breast Cancer : Basic and Clinical Research·Martin J LarsenTorben A Kruse
Dec 3, 2016·BMC Cancer·G ArpinoS De Placido

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

LINKMAP
GeneMapper
Merlin
GWS
Rutgers Map

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.