Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p

Diabetes
Yasumichi MoriP Froguel

Abstract

The genetic background that predisposes the Japanese population to type 2 diabetes is largely unknown. Therefore, we conducted a 10-cM genome-wide scan for type 2 diabetes traits in the 359 affected individuals from 159 families, yielding 224 affected sib-pairs of Japanese origin. Nonparametric multipoint linkage analyses performed in the whole population showed one suggestive linked region on 11p13-p12 (maximum logarithm of odds score [MLS] 3.08, near Pax6) and seven potentially linked regions (MLS >1.17) at 1p36-p32, 2q34, 3q26-q28, 6p23, 7p22-p21, 15q13-q21, and 20q12-q13 (near the gene for hepatocyte nuclear factor-4alpha [HNF-4alpha]). Subset analyses according to maximal BMI and early age at diagnosis added suggestive evidence of linkage with type 2 diabetes at 7p22-p21 (MLS 3.51), 15q13-q21 (MLS 3.91), and 20q12-q13 (MLS 2.32). These results support previous indication for linkage found on chromosome 3q, 15q, and 20q in other populations and identifies two new potential loci on 7p and 11p that may confer genetic risk for type 2 diabetes in the Japanese population.

References

Dec 1, 1992·Annals of Medicine·G A HitmanM Viswanathan
Oct 13, 1995·Biochemical and Biophysical Research Communications·H KadowakiN Yamada
Oct 1, 1994·Diabetes Research and Clinical Practice·R HaguraK Kosaka
Aug 1, 1994·The Journal of Clinical Endocrinology and Metabolism·S VijayaraghavanP G Kopelman
Sep 1, 1994·The Journal of Clinical Endocrinology and Metabolism·S OtabeY Yazaki
Apr 7, 1994·The New England Journal of Medicine·T KadowakiY Goto
Feb 1, 1997·European Journal of Clinical Nutrition·A Rauscher, S Fairweather-Tait
Jun 23, 1998·American Journal of Human Genetics·J R O'Connell, D E Weeks
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·S GhoshM Boehnke
Apr 25, 2000·Biochemical and Biophysical Research Communications·K HaraT Kadowaki
Sep 13, 2000·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·K SakuraiA Kanatsuka
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·A H KissebahA G Comuzzie
Apr 21, 2001·European Journal of Human Genetics : EJHG·S HorvathN M Laird

❮ Previous
Next ❯

Citations

May 25, 2005·Der Internist·Y BöttcherM Stumvoll
Nov 27, 2010·Pflügers Archiv : European journal of physiology·Zhiming ZhuDaoyan Liu
Apr 22, 2005·Human Genetics·Beth S SuttonDonald W Bowden
Feb 9, 2008·Journal of Human Genetics·F TakeuchiN Kato
Mar 15, 2011·Molecular Biology Reports·Nasser M Al-DaghriTajamul Hussain
May 6, 2003·Current Diabetes Reports·Francis VasseurPhilippe Froguel
May 6, 2003·Current Diabetes Reports·Mark I McCarthy
May 6, 2003·Current Diabetes Reports·Robert L Hanson, William C Knowler
Mar 30, 2005·Current Diabetes Reports·Karen L Mohlke, Michael Boehnke
Jun 1, 2005·Archives of Medical Research·María Teresa Tusié Luna
Mar 21, 2003·Biochemical and Biophysical Research Communications·Makoto DaimonTakeo Kato
Feb 6, 2003·American Journal of Preventive Medicine·Tabitha A HarrisonKaren L Edwards
Oct 3, 2002·Molecular Genetics and Metabolism·Simon M S Mitchell, Timothy M Frayling
Aug 20, 2008·Nature Genetics·Kazuki YasudaMasato Kasuga
Feb 14, 2006·Diabetes Technology & Therapeutics·Jose-Manuel Fernández-Real
Nov 13, 2008·Human Molecular Genetics·Véronique Serre-BeinierPaolo Meda
Mar 14, 2007·Current Opinion in Lipidology·E Shyong Tai, Jose M Ordovas
Mar 15, 2012·Clinical and Experimental Pharmacology & Physiology·Xing-Ping DaiZhao-Qian Liu
Oct 9, 2007·Diabetes, Obesity & Metabolism·S BavamianP Meda
Oct 13, 2009·Diabetes, Obesity & Metabolism·R Jain, E Lammert
Oct 7, 2003·Annual Review of Genomics and Human Genetics·Jose C FlorezDavid Altshuler
Nov 28, 2007·Annual Review of Pathology·Hironori Waki, Peter Tontonoz
Jan 29, 2008·Human Heredity·Weihua GuanUNKNOWN International Type 2 Diabetes Linkage Analysis Consortium
Jul 11, 2006·The Journal of Clinical Investigation·Takashi KadowakiKazuyuki Tobe
Mar 2, 2010·BMC Medical Genetics·Rubina TabassumDwaipayan Bharadwaj
Mar 16, 2007·PloS One·Jenny FredrikssonUNKNOWN Botnia Study Group
Nov 8, 2007·PloS One·Martins KalisCorrado M Cilio
Jun 15, 2007·The Review of Diabetic Studies : RDS·George V Z DedoussisDemosthenes B Panagiotakos
Sep 5, 2008·Molecular Medicine·L Jorge GóñezLeonard C Harrison

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Diabetes Association Journals

Discover the latest diabetes research published by the journals from the American Diabetes Association.