Genome-wide search reveals the existence of a limited number of thyroid hormone receptor alpha target genes in cerebellar neurons.

PloS One
Fabrice ChatonnetFrédéric Flamant

Abstract

Thyroid hormone (T3) has a major influence on cerebellum post-natal development. The major phenotypic landmark of exposure to low levels of T3 during development (hypothyroidism) in the cerebellum is the retarded inward migration of the most numerous cell type, granular neurons. In order to identify the direct genetic regulation exerted by T3 on cerebellar neurons and their precursors, we used microarray RNA hybridization to perform a time course analysis of T3 induced gene expression in primary cultures of cerebellar neuronal cell. These experiments suggest that we identified a small set of genes which are directly regulated, both in vivo and in vitro, during cerebellum post-natal development. These modest changes suggest that T3 does not acts directly on granular neurons and mainly indirectly influences the cellular interactions taking place during development.

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Citations

Sep 5, 2013·Thyroid : Official Journal of the American Thyroid Association·Antonio C BiancoUNKNOWN American Thyroid Association Task Force on Approaches and Strategies to Investigate Thyroid Hormone Economy and Action
Feb 6, 2013·Proceedings of the National Academy of Sciences of the United States of America·Fabrice ChatonnetFrederic Flamant
Oct 1, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Erika SawanoTomoko Tashiro
Dec 19, 2012·Neuroscience·A Shulga, C Rivera
Dec 3, 2014·Journal of Neuroscience Research·Koshi OyanagiTomoko Tashiro
Jun 3, 2014·Biochimica Et Biophysica Acta·F ChatonnetB Morte
Dec 10, 2014·Molecular Reproduction and Development·Fabrice ChatonnetFrédéric Flamant
May 5, 2017·Endocrinology·Frédéric FlamantSamuel Refetoff
Mar 13, 2014·Molecular Endocrinology·Frédéric PicouFrédéric Flamant
Feb 11, 2020·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Anna GöbelThomas F Münte
Oct 31, 2020·Journal of the Endocrine Society·Cícera P MarcelinoAntonio C Bianco

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Datasets Mentioned

BETA
GSE24793

Methods Mentioned

BETA
Affinity Purification
transgenic
electrophoresis
Reverse Transcription-PCR
PCR
transfection

Software Mentioned

Nubiscan
Affymetrix MAS5
Affymetrix GCOS

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