Genome-wide transcriptional regulation of estrogen receptor targets in fallopian tube cells and the role of selective estrogen receptor modulators

Journal of Ovarian Research
Georgette Moyle-HeyrmanJoanna E Burdette

Abstract

The fallopian tube epithelium is one of the potential sources of high-grade serous ovarian cancer (HGSC). The use of estrogen only hormone replacement therapy increases ovarian cancer (OVCA) risk. Despite estrogen's influence in OVCA, selective estrogen receptor modulators (SERMs) typically demonstrate only a 20 % response rate. This low response could be due to a variety of factors including the loss of estrogen receptor signaling or the role of estrogen in different potential cell types of origin. The response of fallopian tube epithelium to SERMs is not known, and would be useful when determining therapeutic options for tumors arising from this cell type, such as HGSC. Using normal murine derived oviductal epithelial cells (mouse equivalent to the fallopian tube) estrogen receptor expression was confirmed and interaction with its ligand, estradiol, triggered mRNA and protein induction of progesterone receptor (PR). The SERMs 4-hydroxytamoxifen, raloxifene and desmethylarzoxifene, functioned as estrogen receptor antagonists in oviductal cells. Cellular proliferation and migration assays suggested that estradiol does not significantly impact cellular migration and increased proliferation. Further, using RNAseq, the oviduct spe...Continue Reading

References

Jul 4, 1990·Journal of the National Cancer Institute·P SkehanM R Boyd
May 1, 1997·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Y Menezo, P Guerin
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·K M LauS M Ho
Feb 13, 2001·The Journal of Steroid Biochemistry and Molecular Biology·B S KatzenellenbogenJ A Katzenellenbogen
Mar 7, 2001·In Vitro Cellular & Developmental Biology. Animal·W BaiS V Nicosia
May 4, 2002·Molecular and Cellular Endocrinology·Haim Breitbart
Jul 16, 2002·JAMA : the Journal of the American Medical Association·James V LaceyCatherine Schairer
Dec 10, 2002·Reproductive Biomedicine Online·Horacio B Croxatto
Jul 23, 2003·Chemical Research in Toxicology·Xuemei LiuJudy L Bolton
Mar 12, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Debra A Bell
Sep 8, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rebecca T MarquezKaren H Lu
Jan 5, 2006·Molecular Pharmacology·Patrick AugereauVincent Cavailles
Mar 28, 2006·Human Reproduction Update·R A LyonsO Djahanbakhch
Jan 6, 2007·Genome Biology·Pedro Carmona-SaezAlberto Pascual-Montano
Sep 22, 2007·Journal of Cellular Physiology·Boris J CheskisLeonard P Freedman
May 26, 2009·Nucleic Acids Research·Ruben Nogales-CadenasAlberto Pascual-Montano
Jul 25, 2009·Endocrine-related Cancer·Willem-Jan WelborenHendrik G Stunnenberg
Oct 21, 2010·Cancer Research·Monique A SpillmanKathryn B Horwitz
Apr 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Alison M KarstRonny Drapkin
Jul 2, 2011·Nature·UNKNOWN Cancer Genome Atlas Research Network
Aug 17, 2011·Nature Reviews. Endocrinology·Eric R Prossnitz, Matthias Barton
Mar 13, 2012·Journal of Hematology & Oncology·Jie LiWenxin Zheng
Apr 17, 2012·Current Obstetrics and Gynecology Reports·Elisabetta KuhnIe-Ming Shih
May 2, 2012·Proceedings of the National Academy of Sciences of the United States of America·Keiichiro SakumaReiji Kannagi
May 11, 2012·Nucleic Acids Research·Daniel Tabas-MadridAlberto Pascual-Montano
Apr 4, 2013·Science Signaling·Jianjiong GaoNikolaus Schultz
Jul 11, 2013·Nature Communications·Silvia DomckeNikolaus Schultz
Aug 21, 2013·ChemMedChem·Hitisha K PatelGregory R J Thatcher
Jun 4, 2014·CA: a Cancer Journal for Clinicians·Carol E DeSantisAhmedin Jemal
Jul 8, 2014·European Journal of Histochemistry : EJH·G CheneF Penault Llorca
Jul 16, 2014·Bioconjugate Chemistry·Taryn R TownsendThomas J Meade
Dec 21, 2014·Gynecologic Oncology·Sharon L EddieJoanna E Burdette
Feb 17, 2015·Lancet·UNKNOWN Collaborative Group On Epidemiological Studies Of Ovarian CancerR Peto

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Citations

Oct 9, 2018·The Journal of Clinical Endocrinology and Metabolism·Geoffrey D MillerDaniel Eichner
Sep 10, 2020·Journal of Cellular Physiology·Mitrasadat RezaeiRamin Pouriran
Jan 12, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Courtney L AndersenSteffi Oesterreich
Sep 11, 2018·Journal of Natural Products·Jung-Ho LeeBrian T Murphy

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Datasets Mentioned

BETA
GSE67207

Methods Mentioned

BETA
hormone replacement therapy
RNAseq
transfection
Illumina sequencing
PCR
xenografts

Software Mentioned

GraphPad Prism
GeneCoDis
ImageJ
cuffdiff
Cufflinks
FastQC
TopHat
RNAseq

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