Genome-wide variants of Eurasian facial shape differentiation and a prospective model of DNA based face prediction.

Journal of Genetics and Genomics = Yi Chuan Xue Bao
Lu QiaoKun Tang

Abstract

It is a long-standing question as to which genes define the characteristic facial features among different ethnic groups. In this study, we use Uyghurs, an ancient admixed population to query the genetic bases why Europeans and Han Chinese look different. Facial traits were analyzed based on high-dense 3D facial images; numerous biometric spaces were examined for divergent facial features between European and Han Chinese, ranging from inter-landmark distances to dense shape geometrics. Genome-wide association studies (GWAS) were conducted on a discovery panel of Uyghurs. Six significant loci were identified, four of which, rs1868752, rs118078182, rs60159418 at or near UBASH3B, COL23A1, PCDH7 and rs17868256 were replicated in independent cohorts of Uyghurs or Southern Han Chinese. A prospective model was also developed to predict 3D faces based on top GWAS signals and tested in hypothetic forensic scenarios.

Citations

Nov 26, 2019·ELife·Ziyi XiongUNKNOWN International Visible Trait Genetics (VisiGen) Consortium
Dec 9, 2020·Nature Genetics·Julie D WhitePeter Claes
Feb 18, 2021·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Yin HuangStefan Grünewald
Nov 19, 2021·Human Molecular Genetics·Maria J KnolHieab H H Adams

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