Genomewide association analyses of electrophysiological endophenotypes for schizophrenia and psychotic bipolar disorders: a preliminary report

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Mei-Hua HallJordan W Smoller

Abstract

Several event-related potentials (ERP), including P3, sensory gating (P50), and gamma oscillation, are robustly impaired in patients with schizophrenia (SCZ) and bipolar disorder (BIP). Although these ERPs are known to be heritable, little is known about the specific genetic loci involved and the degree to which they overlap with loci influencing mood and psychotic disorders. In the present study, we conducted GWAS to a) identify common variants associated with ERP endophenotypes, and b) construct polygenic risk scores (PRS) to examine overlap between genetic components of ERPs and mood and psychotic disorders. The sample consisted of 271 patients with SCZ or psychotic BIP diagnosis and 128 controls for whom ERP and genomewide data were available. GWAS were conducted using the full sample. PRS, derived from the Psychiatric Genomics Consortium (PGC) analyses of SCZ, BIP, and major depressive disorder were applied to each ERP phenotype. We identified a region on chromosome 14 that was significantly associated with sensory gating (peak SNP rs10132223, P = 1.27 × 10(-9) ). This locus has not been previously associated with psychotic illness in PGC-GWAS. In the PRS analyses, patients with a higher load of SCZ risk alleles had reduce...Continue Reading

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Citations

Mar 13, 2016·Psychiatry and Clinical Neurosciences·Massimiliano BuoliA Carlo Altamura
Jun 14, 2016·Journal of Affective Disorders·Chia-Hsiung ChengShih-Chieh Hsu
Jun 25, 2017·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ayla Arslan
Apr 7, 2018·The Journal of Headache and Pain·Mona Ameri ChalmerThomas Folkmann Hansen
Mar 27, 2018·Annual Review of Clinical Psychology·Ryan BogdanArpana Agrawal
Aug 30, 2017·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Siri RanlundElvira Bramon
Mar 10, 2016·Harvard Review of Psychiatry·Emily M OwensCarrie E Bearden
Jun 15, 2019·Journal of Affective Disorders·Masataka WadaYoshihiro Noda

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