Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02).

The Journal of Infectious Diseases
Sophie LimouANRS Genomic Group

Abstract

To elucidate the genetic factors predisposing to AIDS progression, we analyzed a unique cohort of 275 human immunodeficiency virus (HIV) type 1-seropositive nonprogressor patients in relation to a control group of 1352 seronegative individuals in a genomewide association study (GWAS). The strongest association was obtained for HCP5 rs2395029 (P=6.79x10(-10); odds ratio, 3.47) and was possibly linked to an effect of sex. Interestingly, this single-nucleotide polymorphism (SNP) was in high linkage disequilibrium with HLA-B, MICB, TNF, and several other HLA locus SNPs and haplotypes. A meta-analysis of our genomic data combined with data from the previously conducted Euro-CHAVI (Center for HIV/AIDS Vaccine Immunology) GWAS confirmed the HCP5 signal (P=3.02x10(-19)) and identified several new associations, all of them involving HLA genes: MICB, TNF, RDBP, BAT1-5, PSORS1C1, and HLA-C. Finally, stratification by HCP5 rs2395029 genotypes emphasized an independent role for ZNRD1, also in the HLA locus, and this finding was confirmed by experimental data. The present study, the first GWAS of HIV-1 nonprogressors, underscores the potential for some HLA genes to control disease progression soon after infection.

References

Nov 1, 1996·The Journal of Experimental Medicine·P D RennertP S Hochman
Jun 3, 2000·Genetics·J K PritchardP Donnelly
Apr 21, 2001·Biometrics·B Devlin, K Roeder
May 31, 2001·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·R J AllcockP Price
Feb 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pedro O Flores-VillanuevaJean-François Zagury
Sep 10, 2003·Antiviral Chemistry & Chemotherapy·K Kedzierska, S M Crowe
Mar 17, 2004·Arthritis and Rheumatism·Rachael KildingAnthony G Wilson
May 29, 2004·Nature Genetics·Stephen J O'Brien, George W Nelson
Dec 17, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Cheryl A WinklerJean-François Zagury
Jan 5, 2005·Trends in Immunology·Henry A F Stephens
Mar 25, 2005·American Journal of Human Genetics·Janis E WiggintonGoncalo R Abecasis
May 16, 2006·Human Immunology·Sandra Rodriguez-RoderoCarlos Lopez-Larrea
Jun 7, 2007·JAMA : the Journal of the American Medical Association·John W MellorsAlvaro Muñoz
Jul 21, 2007·Science·Jacques FellayDavid B Goldstein
Feb 16, 2008·Nature Reviews. Drug Discovery·Stephen F KingsmoreWilliam D Beavis

❮ Previous
Next ❯

Citations

Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Brenna M HennMarcus W Feldman
Jun 23, 2010·The Journal of Experimental Medicine·Stephanie GrasScott R Burrows
Aug 12, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Zabrina BrummeElena Losina
Mar 26, 2011·Briefings in Functional Genomics·Melanie J Newport, Chris Finan
Nov 22, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dshanta D NaickerThumbi Ndung'u
Jun 22, 2012·Human Molecular Genetics·Paul J McLarenUNKNOWN International HIV Controllers Study
Nov 1, 2013·ILAR Journal·Shu ShenDaniel E Geraghty
Apr 20, 2011·The Journal of Infectious Diseases·Jennifer L TroyerStephen J O'Brien
Mar 1, 2012·The Journal of Infectious Diseases·Sophie LimouJean-François Zagury
Aug 15, 2014·AIDS·Mary CarringtonPaul J McLaren
Nov 26, 2009·AIDS·Woohyun YoonUNKNOWN NIAID Center for HIV/AIDS Vaccine Immunology
May 15, 2010·AIDS·Adam M SpivakJoel E Gallant
Dec 17, 2010·AIDS·Slavé PetrovskiUNKNOWN Center for HIV/AIDS Vaccine Immunology
Aug 24, 2011·AIDS·Daniëlle van ManenUNKNOWN Dutch HIV monitoring foundation HIV-1 Host Genetics study
Nov 26, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Sigrid Le ClercJean-François Zagury
Feb 9, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·John Novembre, Eunjung Han
Apr 5, 2012·Cold Spring Harbor Perspectives in Medicine·Amalio Telenti, Welkin E Johnson
Apr 16, 2009·Clinical Microbiology Reviews·Jenefer M BlackwellDavid Burgner
Oct 12, 2012·Journal of Virology·Robert W BuckheitJoel N Blankson
Jun 22, 2011·BMC Evolutionary Biology·Yann C KlimentidisSadeep Shrestha
Aug 28, 2012·Retrovirology·Daniëlle van ManenHanneke Schuitemaker
Feb 2, 2013·Genome Biology·Stephen J O'Brien, Sher L Hendrickson
Dec 31, 2009·PLoS Genetics·Jacques FellayUNKNOWN NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI)
Dec 17, 2011·PloS One·Jairam R LingappaUNKNOWN Partners in Prevention HSV/HIV Transmission Study Team

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved