Genomewide association study reveals novel genetic loci associated with change in renal function in heart transplant recipients

Clinical Transplantation
Rabea AslehNaveen L Pereira

Abstract

Renal dysfunction occurs commonly after heart transplantation (HTx) with wide inter-individual variability but whether a genetic predisposition exists in these patients is unknown. Genomewide association studies (GWAS) have not been performed to assess the association of genetic variation with change in renal function after HTx. Clinical and demographic data of patients who underwent HTx and provided blood samples and consent for genetic analysis were included. Genotyping was performed using Illumina Infinium Human CoreExome v1.0 analysis kit. A GWAS utilizing linear regression models was performed with estimated glomerular filtration rate (eGFR) at 1 year as the phenotype after adjusting for baseline eGFR prior to HTx and conversion from calcineurin inhibitor to sirolimus as primary immunosuppression therapy. A total of 251 HTx recipients were genotyped for 314,903 single nucleotide polymorphisms (SNPs). The mean (SD) age was 50 (12.5) years; most patients were of European origin (n = 243, 96.8%) and males (n = 179, 71.3%). After adjustment for potential confounders, two variants, rs17033285 (P = 4.3 × 10-7 ) and rs4917601 (P = 6.46 × 10-7 ), in a long non-coding RNA (lncRNA) gene LINC01121 and a pseudogene BTBD7P2, were ident...Continue Reading

References

Apr 1, 1992·Kidney International·K Borch-JohnsenH H Parving
Jan 1, 1995·Annual Review of Nutrition·N P Curthoys, M Watford
Sep 24, 1999·Current Opinion in Nephrology and Hypertension·J R SchellingJ R Sedor
Sep 5, 2003·The New England Journal of Medicine·Akinlolu O OjoRobert M Merion
Oct 29, 2005·Nature·UNKNOWN International HapMap Consortium
May 5, 2007·Science·Ruth McPhersonJonathan C Cohen
Jun 8, 2007·Nature·UNKNOWN Wellcome Trust Case Control Consortium
Oct 5, 2007·Kidney International·H IbrahimN P Curthoys
Jan 6, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M CantarovichM E Edwardes
Aug 27, 2009·Nature Reviews. Cardiology·Naveen L Pereira, Richard M Weinshilboum
Jan 1, 2010·Clinical Transplantation·Daniela KniepeissKarl-Heinz Tscheliessnigg
Apr 13, 2010·Nature Genetics·Anna KöttgenCaroline S Fox
Jan 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·Thomas P CappolaGerald W Dorn
Apr 9, 2011·Journal of the American Society of Nephrology : JASN·Stewart H Lecker, William E Mitch
Jun 30, 2011·Nature Reviews. Nephrology·Paul E Drawz, John R Sedor
Jan 17, 2012·American Journal of Human Genetics·Peter M VisscherJian Yang
Apr 6, 2012·PLoS Genetics·Cristian PattaroCaroline S Fox
Mar 7, 2013·Nature Structural & Molecular Biology·Tim R Mercer, John S Mattick
Sep 3, 2013·Clinical Pharmacology and Therapeutics·T van GelderD A Hesselink
Aug 2, 2014·Human Molecular Genetics·Gardar SveinbjornssonKari Stefansson
Oct 30, 2014·Journal of Internal Medicine·M Ingelman-Sundberg
Feb 14, 2015·Circulation Research·Shizuka Uchida, Stefanie Dimmeler
May 6, 2015·Nature Reviews. Cardiology·Naveen L PereiraCharanjit S Rihal
Jun 6, 2015·Mayo Clinic Proceedings·Naveen L Pereira, A Keith Stewart
Jun 13, 2015·Pharmacogenomics·Rebecca A PulkUNKNOWN DeKAF Investigators
Jun 25, 2015·Pharmacogenomics·Ignacio Sánchez-LázaroSalvador F Aliño
Oct 12, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Roger D YusenJosef Stehlik
Dec 17, 2015·The Pharmacogenomics Journal·K SanghaviP A Jacobson
Mar 17, 2016·Advances in Chronic Kidney Disease·Girish N Nadkarni, Carol R Horowitz
Mar 26, 2016·Frontiers in Immunology·Marieke GriffioenJ H Frederik Falkenburg
Apr 14, 2016·The New England Journal of Medicine·Robert J BlendonJohn M Benson
Jun 1, 2016·Frontiers in Pharmacology·Paola ImbriciDiana Conte
Aug 23, 2016·Nature Genetics·Shane McCarthyUNKNOWN Haplotype Reference Consortium
Aug 30, 2016·Nature Genetics·Sayantan DasChristian Fuchsberger
Sep 20, 2016·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Avishay GrupperSudhir S Kushwaha
Oct 13, 2016·Journal of the American Society of Nephrology : JASN·Afshin ParsaUNKNOWN and the Chronic Renal Insufficiency Cohort (CRIC) Study Investigators
Nov 2, 2016·The Journal of Clinical Investigation·Jianyin LongFarhad R Danesh
Oct 25, 2016·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Lars H LundUNKNOWN International Society for Heart and Lung Transplantation
Mar 8, 2017·Current Opinion in Organ Transplantation·Kiran K Khush
Aug 7, 2017·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Lars H LundUNKNOWN International Society for Heart and Lung Transplantation
Feb 9, 2018·Journal of the American College of Cardiology·Rabea AslehSudhir S Kushwaha

❮ Previous
Next ❯

Citations

Dec 20, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Prasanth PuthanveetilJohan Lorenzen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.