Genomewide linkage scan for opioid dependence and related traits.

American Journal of Human Genetics
Joel GelernterHenry R Kranzler

Abstract

Risk of opioid dependence is genetically influenced. We recruited a sample of 393 small nuclear families (including 250 full-sib and 46 half-sib pairs), each with at least one individual with opioid dependence. Subjects underwent a detailed evaluation of substance dependence-related traits. As planned a priori to reduce heterogeneity, we used cluster analytic methods to identify opioid dependence-related symptom clusters, which were shown to be heritable. We then completed a genomewide linkage scan (with 409 markers) for the opioid-dependence diagnosis and for the two cluster-defined phenotypes represented by >250 families: the heavy-opioid-use cluster and the non-opioid-use cluster. Further exploratory analyses were completed for the other cluster-defined phenotypes. The statistically strongest results were seen with the cluster-defined traits. For the heavy-opioid-use cluster, we observed a LOD score of 3.06 on chromosome 17 (empirical pointwise P = .0002) for European American (EA) and African American (AA) subjects combined, and, for the non-opioid-use cluster, we observed a LOD score of 3.46 elsewhere on chromosome 17 (empirical pointwise P = .00002, uncorrected for multiple traits studied) for EA subjects only. We also id...Continue Reading

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Citations

Aug 8, 2013·Heredity·D GianolaH Simianer
Feb 12, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Carolien I PanhuysenJoel Gelernter
Apr 16, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Pingxing XieJoel Gelernter
Aug 19, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bao-Zhu YangJoel Gelernter
Oct 21, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Pingxing XieJoel Gelernter
Mar 23, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jian CaoDawei Li
Jan 25, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marc N PotenzaJoel Gelernter
Dec 23, 2006·Human Molecular Genetics·Xingguang LuoJoel Gelernter
May 28, 2010·Psychiatric Genetics·Cindy L EhlersKirk C Wilhelmsen
Nov 2, 2013·Human Genetics·Jian CaoDawei Li
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Jul 9, 2008·Drug and Alcohol Dependence·Arpana AgrawalMichael T Lynskey
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Nov 4, 2006·Biological Psychiatry·Joel GelernterHenry R Kranzler
Aug 18, 2009·Addiction·Mark J NiciuHenry R Kranzler
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Feb 11, 2011·Addiction·Grace ChanHenry R Kranzler
Jan 4, 2012·The American Journal on Addictions·Albert J AriasHenry R Kranzler
Jun 10, 2011·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Rungnapa IttiwutJoel Gelernter
Oct 18, 2011·The American Journal on Addictions·Mohammad Reza AflatoonianGioia Heravi
Aug 14, 2012·The American Journal on Addictions·Lance O BauerJoel Gelernter
Mar 6, 2010·Annals of the New York Academy of Sciences·Vadim YuferovMary Jeanne Kreek

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