Genomewide scan identifies susceptibility locus for dyslexia on Xq27 in an extended Dutch family

Journal of Medical Genetics
Carolien G F de KovelGeorge W Padberg

Abstract

Dyslexia is a common disorder with a strong genetic component, but despite significant research effort, the aetiology is still largely unknown. To identify loci contributing to dyslexia risk. This was a genomewide linkage analysis in a single large family. Dutch families with at least two first degree relatives suffering from dyslexia participated in the study. Participants were recruited through an advertisement campaign in papers and magazines. The main outcome measure was linkage between genetic markers and dyslexia phenotype. Using parametric linkage analysis, we found strong evidence for a locus influencing dyslexia on Xq27.3 (multipoint lod = 3.68). Recombinations in two family members flanked an 8 cM region, comprising 11 currently confirmed genes. All four males carrying the risk haplotype had very low scores on the reading tests. The presentation in females was more variable, but 8/9 females carrying the risk haplotype were diagnosed dyslexic by our composite score, so we considered the putative risk allele to be dominant with reduced penetrance. Linkage was not found in an additional collection of affected sibling pairs. A locus influencing dyslexia risk is probably located between markers DXS1227 and DXS8091 on the X...Continue Reading

References

Sep 18, 1991·JAMA : the Journal of the American Medical Association·B F PenningtonJ C DeFries
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Oct 14, 1994·Science·L R CardonJ C DeFries
Nov 5, 1997·American Journal of Human Genetics·A Kong, N J Cox
Jun 23, 1998·American Journal of Human Genetics·J R O'Connell, D E Weeks
Jun 23, 1998·American Journal of Human Genetics·G Schulte-KörneH Remschmidt
Mar 21, 2000·American Journal of Human Genetics·E L GrigorenkoD L Pauls
Aug 5, 2000·American Journal of Human Genetics·E M WijsmanW H Raskind
Oct 5, 2001·Journal of Medical Genetics·J Nopola-HemmiE Widén
Jan 25, 2002·Journal of Child Psychology and Psychiatry, and Allied Disciplines·G Schulte-Körne
Feb 12, 2002·Journal of Medical Genetics·T L PetryshenL L Field
Jun 22, 2002·Current Opinion in Genetics & Development·Barbara Bardoni, Jean-Louis Mandel
Oct 3, 2002·Nature Reviews. Neuroscience·Simon E Fisher, John C DeFries
Sep 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Mikko TaipaleJuha Kere

❮ Previous
Next ❯

Citations

Jan 22, 2010·European Child & Adolescent Psychiatry·Thomas S Scerri, Gerd Schulte-Körne
Mar 24, 2009·Current Psychiatry Reports·Tracey L Petryshen, David L Pauls
May 25, 2006·European Journal of Human Genetics : EJHG·Julie Williams, Michael C O'Donovan
Nov 23, 2006·European Journal of Human Genetics : EJHG·Timothy C BatesNicholas G Martin
Feb 21, 2007·Genes, Brain, and Behavior·C MarinoM Molteni
Feb 20, 2007·Journal of Medical Genetics·Johannes SchumacherMarkus M Nöthen
Oct 29, 2005·PLoS Genetics·Katariina Hannula-JouppiJuha Kere
Nov 10, 2010·PloS One·Thomas S ScerriAlex J Richardson
Dec 17, 2008·Journal of Neurogenetics·Jillian M CoutoCathy L Barr
Oct 11, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Rui KongRanran Song
Dec 15, 2005·Pediatric Rehabilitation·Dirk J Bakker
Feb 11, 2016·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Mark A EckertUNKNOWN Dyslexia Data Consortium
Nov 26, 2010·Neurología : publicación oficial de la Sociedad Española de Neurología·A Benítez-Burraco
Dec 17, 2008·Journal of School Psychology·Virginia W BerningerWendy Raskind
Feb 28, 2007·Mental Retardation and Developmental Disabilities Research Reviews·Shelley D Smith
May 19, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Emrah Caylak
Jun 4, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·G PoelmansC Schrander-Stumpel
Apr 24, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Zoran BrkanacWendy H Raskind
Sep 22, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Carolien G F de KovelDavid Pauls
Oct 18, 2013·Dyslexia : the Journal of the British Dyslexia Association·Amaia Carrion-CastilloSimon E Fisher
Jul 1, 2011·Wiley Interdisciplinary Reviews. Cognitive Science·Juha Kere
Jul 10, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jillian M CoutoCathy L Barr
Jan 1, 2014·Genes, Brain, and Behavior·B MuellerH Kirsten
Jan 19, 2015·Neuropsychology Review·Sarah A GrahamSimon E Fisher
May 6, 2006·Trends in Cognitive Sciences·Simon E Fisher, Clyde Francks
Dec 5, 2017·Brain and Behavior·Bent MüllerArndt Wilcke
Nov 10, 2006·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·Gerd Schulte-KörneHelmut Remschmidt
May 29, 2020·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Iliana I Karipidis, David S Hong
Jan 18, 2008·Pró-fono : revista de atualização científica·Simone Aparecida CapelliniLucilene Arilho Ribeiro
Nov 12, 2020·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·Tiemo GrimmAndreas W Kuss
Jun 3, 2021·Brain Sciences·Marianthi GeorgitsiEleni Bonti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Medical Genetics
Jaana Nopola-HemmiE Widén
Journal of Medical Genetics
Jaana Nopola-HemmiJuha Kere
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Nicola H ChapmanWendy H Raskind
© 2021 Meta ULC. All rights reserved