Genomic Alterations in Liquid Biopsies from Patients with Bladder Cancer

European Urology
Karin Birkenkamp-DemtröderLars Dyrskjøt

Abstract

At least half of the patients diagnosed with non-muscle-invasive bladder cancer (NMIBC) experience recurrence and approximately 15% will develop progression to muscle invasive or metastatic disease. Biomarkers for disease surveillance are urgently needed. Development of assays for surveillance using genomic variants in cell-free tumour DNA from plasma and urine. Retrospective pilot study of 377 samples from 12 patients with recurrent or progressive/metastatic disease. Three next-generation sequencing methods were applied and somatic variants in DNA from tumour, plasma, and urine were subsequently monitored by personalised assays using droplet digital polymerase chain reaction (ddPCR). Samples were collected from 1994 to 2015, with up to 20 yr of follow-up. Progression to muscle-invasive or metastatic bladder cancer; t test for ddPCR data. We developed from one to six personalised assays per patient. Patients with progressive disease showed significantly higher levels of tumour DNA in plasma and urine before disease progression, compared with patients with recurrent disease (p=0.032 and 1.3×10(-6), respectively). Interestingly, tumour DNA was detected in plasma and urine in patients with noninvasive disease, being no longer dete...Continue Reading

References

Mar 3, 2004·Nature Reviews. Cancer·P Andrew FutrealMichael R Stratton
Jun 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lars DyrskjøtTorben F Orntoft
Feb 3, 2009·Clinical Chemistry·Eugene M ShekhtmanSamuil R Umansky
Dec 1, 2012·Science Translational Medicine·Rebecca J LearyVictor E Velculescu
May 8, 2013·PloS One·Cristina Balbás-MartínezFrancisco X Real
Jul 6, 2013·European Urology·Marko BabjukUNKNOWN European Association of Urology
Jul 28, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jeffrey S RossPhilip J Stephens
Jul 31, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gopa IyerDavid B Solit
Aug 16, 2013·Nature·Ludmil B AlexandrovMichael R Stratton
Oct 15, 2013·Nature Genetics·Cristina Balbás-MartínezFrancisco X Real
Feb 21, 2014·Science Translational Medicine·Chetan BettegowdaLuis A Diaz
May 20, 2014·Cell Reports·Iver NordentoftTorben F Ørntoft
Aug 12, 2014·Breast Cancer Research : BCR·Maryam HeidaryMichael R Speicher
Nov 13, 2014·Clinical Chemistry·Ellen HeitzerJochen B Geigl
Dec 24, 2014·Nature Reviews. Cancer·Margaret A Knowles, Carolyn D Hurst
Apr 9, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J TieP Gibbs
Apr 19, 2015·Clinical Biochemistry·K M Patel, D W Y Tsui
Jul 15, 2015·Journal of Hematology & Oncology·Xu ZhangWenrong Xu
Aug 28, 2015·Science Translational Medicine·Isaac Garcia-MurillasNicholas C Turner
Nov 4, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michail IgnatiadisStefanie S Jeffrey

❮ Previous
Next ❯

Citations

Mar 10, 2016·European Urology·Cyrill A RentschLukas Bubendorf
Jun 21, 2016·Cancer Cell·Jakob HedegaardLars Dyrskjøt
Sep 13, 2016·Investigative and Clinical Urology·Minyong Kang, Ja Hyeon Ku
Nov 1, 2016·Expert Review of Molecular Diagnostics·Samanta SalviValentina Casadio
Sep 7, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Alberto Contreras-SanzPeter C Black
Dec 3, 2016·The Journal of Urology·Peter C Black
Jul 27, 2017·Pharmacogenomics·Tahlita Cm Zuiverloon, Dan Theodorescu
Dec 22, 2017·British Journal of Haematology·Yinlei BaiChor Sang Chim
May 1, 2018·Expert Review of Molecular Diagnostics·Moritz MaasTilman Todenhöfer
Aug 31, 2018·International Journal of Molecular Sciences·Melissa P TanRobert A Huddart
Aug 24, 2018·Current Opinion in Urology·Lars Dyrskjøt, Molly A Ingersoll
Oct 29, 2018·Annals of Hematology·Fang-Tian WuJian-Yong Li
Feb 1, 2018·Scientific Reports·Emil ChristensenLars Dyrskjøt
Oct 28, 2018·Cellular Oncology (Dordrecht)·Heidi FettkeArun A Azad
Feb 13, 2018·Bladder Cancer·Tilman TodenhöferPeter C Black
Oct 15, 2019·Expert Review of Molecular Diagnostics·Erik KoubaLiang Cheng
Oct 18, 2019·Current Molecular Pharmacology·Samira BahramiAmirhossein Sahebkar
Oct 18, 2016·Oncotarget·Joshua J MeeksFrancis J Giles
May 31, 2020·Cancers·Drahomír KolenčíkPeter Kuhn
Jun 28, 2020·Cancer Medicine·Ana Carolina Kerekes MiguezDirce Maria Carraro
May 10, 2017·Molecular Diagnosis & Therapy·Susana Olmedillas-LópezDamián García-Olmo
Aug 22, 2018·Frontiers in Pharmacology·Kha Wai HonRahman Jamal
May 7, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Emil ChristensenLars Dyrskjøt
Feb 23, 2020·International Journal of Molecular Sciences·Jennifer S WinnSandra V Fernandez
Apr 8, 2020·BioMed Research International·Yuhan DingLei Ding
Feb 25, 2017·Nature Reviews. Cancer·Jonathan C M WanNitzan Rosenfeld
Sep 20, 2019·International Journal of Molecular Sciences·Eman A TahaTakanori Eguchi
Jul 15, 2017·The International Journal of Biological Markers·Fang TianYanfang Zhang
May 11, 2018·Der Urologe. Ausg. A·D ZaakA Stenzl
Dec 14, 2018·World Journal of Urology·David J McConkey, Seth P Lerner
Apr 4, 2019·Molecular Diagnosis & Therapy·Re-I ChinAadel A Chaudhuri
Dec 6, 2019·Frontiers in Oncology·Uttam SatyalPhilip H Abbosh
Jan 16, 2020·Clinical and Translational Medicine·Zhenyu OuZhuo Song
Dec 31, 2016·Bladder Cancer·Lakshminarayanan Nandagopal, Guru Sonpavde

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Sequencing

Several sequencing approaches are employed to understand and examine tumor development and progression. These include whole genome as well as RNA sequencing. Here is the latest research on cancer sequencing.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Related Papers

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Charles J RosserSteve Goodison
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
David ChuBen Ho Park
© 2021 Meta ULC. All rights reserved