PMID: 11908758Mar 23, 2002Paper

Genomic analysis of a mouse model of immunoglobulin A nephropathy reveals an enhanced PDGF-EDG5 cascade

The Pharmacogenomics Journal
S KatsumaG Tsujimoto

Abstract

The molecular mechanism of immunoglobulin A nephropathy (IgAN), the most common primary renal glomerular disease worldwide, is unknown. HIGA (high serum IgA) mouse is a valid model of IgAN showing almost all of the pathological features, including mesangial cell proliferation. Here we elucidate a pattern of gene expression associated with IgAN by analyzing the diseased kidneys on cDNA microarrays. In particular, we showed an enhanced expression of several genes regulating the cell cycle and proliferation, including growth factors and their receptors, as well as endothelial differentiation gene-5 (EDG5), a receptor for sphingosine 1-phosphate (SPP). One of the growth factors, platelet-derived growth factor (PDGF) induces a marked upregulation of EDG5 in proliferative mesangial cells, and promotes cell proliferation synergistically with SPP. The genomic approach allows us to identify families of genes involved in a process, and can indicate that enhanced PDGF-EDG5 signaling plays an important role in the progression of IgAN.

References

Sep 1, 1992·The American Journal of Physiology·P KotankoF Skrabal
Jan 1, 1991·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M NakajimaP Kincaid-Smith
Feb 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·W G Couser, R J Johnson
Feb 15, 1993·Biochemical and Biophysical Research Communications·H OkazakiY Takuwa
Nov 1, 1995·Kidney International·Z I NiemirR Waldherr
Sep 1, 1996·Genome Research·M F BonaldoM B Soares
Jan 1, 1997·American Journal of Nephrology·M MatsudaZ Ota
Aug 26, 1998·Regulatory Peptides·N C KallincosJ J Couper
Dec 16, 1998·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·M B WangE S Srivatsan
Apr 24, 1999·Journal of the American Society of Nephrology : JASN·S SuzukiF Gejyo
Feb 10, 2000·Advances in Experimental Medicine and Biology·E J Goetzl, S An
Mar 14, 2000·Cell Death and Differentiation·K B Sandau, B Brüne
May 16, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S R OrthC Suter-Crazzolara
Jun 1, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·H YamabeK Okumura
Jun 23, 2000·Journal of the American Society of Nephrology : JASN·Stephen ThomasGiancarlo Viberti
Jul 6, 2000·The Biochemical Journal·S Pyne, N J Pyne

❮ Previous
Next ❯

Citations

Nov 2, 2001·Biochemical and Biophysical Research Communications·S KatsumaG Tsujimoto
Sep 3, 2003·Biochemical and Biophysical Research Communications·Kazuchika TakagakiJunichi Yano
May 18, 2005·Proceedings of the National Academy of Sciences of the United States of America·Masateru YamadaGozoh Tsujimoto
Aug 12, 2008·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Tadashi Nagamatsu
Mar 6, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Toshiyuki ImasawaYutaka Yatomi
Mar 22, 2008·Life Sciences·Hiromitsu YoshimuraTadashi Nagamatsu
Oct 2, 2001·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·K Ishikawa, G Tsujimoto
Jul 20, 2010·Biochemical and Biophysical Research Communications·Koki TokunagaHirohito Tsubouchi
Dec 18, 2002·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Susumu KatsumaGozoh Tsujimoto
Jan 11, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Makoto KuranoYutaka Yatomi
May 20, 2015·International Journal of Neural Systems·Yanli ZhangShasha Yuan
Jul 2, 2018·The Journal of the Acoustical Society of America·Angeliki XenakiMads Græsbøll Christensen
Jan 17, 2019·The Journal of Chemical Physics·Markus SchöberlPhaedon-Stelios Koutsourelakis
Apr 28, 2005·Antimicrobial Agents and Chemotherapy·Yoshihiro InoueShigeki Kobayashi
Apr 2, 2008·Annals of the New York Academy of Sciences·Yuchen Liu, William B Whitman
Dec 31, 2020·Journal of the American Society of Nephrology : JASN·Yelena DrexlerSandra Merscher

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.