Genomic analysis of Epstein-Barr virus in nasal and peripheral T-cell lymphoma: a comparison with nasopharyngeal carcinoma in an endemic area

Journal of Medical Virology
S J WuI J Su

Abstract

The Epstein-Barr virus (EBV) is prevalent in nasal and peripheral T-cell lymphoma (NPTL) in Taiwan, where nasopharyngeal carcinoma (NPC) is endemic. In order to understand the pathogenesis of these two malignancies in this endemic area, genomic analysis of EBV in NPTL with comparison to NPC is important. We investigated the EBV subtype (types A and B), BamH-I "f" variant, and the Xho-I site mutant of the latent membrane protein-1 (LMP-1) gene in 19 cases of EBV-associated NPTL and in 30 cases of NPC. EBV DNA from three patients with infectious mononucleosis (IM) was simultaneously studied as representative of normal healthy carriers. Similar to NPC and IM, the EBV in NPTL was found to belong to the type A strain in the majority (18 of 19) of cases by analyzing the 3' divergence of EBNA-2 genes. The extra restriction enzyme site in the BamHI-F region ("f" variant) of EBV DNA was frequently (15 of 30) demonstrated in NPC, but only rarely (1 of 19) was it detected in NPTL and IM (0 of 3). The Xho-I site mutant of the LMP-1 gene previously characterized in Chinese NPC also prevailed in NPTL and IM with an identical nucleotide sequence. No correlation exists between the EBV subtype and its variants. In conclusion, type A EBV is prev...Continue Reading

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Citations

Jul 17, 2007·Diagnostic Pathology·Afshin AbdiradSuminori Akiba
Mar 18, 2008·Human Pathology·Andrea T Deyrup
Aug 20, 2010·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Qiuyu LiuYu Dong
Sep 16, 2015·Virchows Archiv : an International Journal of Pathology·Wen-Yu ChuangChuen Hsueh
May 1, 1997·Critical Reviews in Oncology/hematology·I J Su, J Y Chen
Jun 13, 1998·American Journal of Ophthalmology·F R HuK H Yeh
Jul 20, 2016·Journal of Medical Virology·Marco NevesHugo Sousa
Dec 8, 2010·International Journal of Surgical Pathology·Yu-Hua HuangJing-Hui Hou
Mar 29, 2002·Journal of Medical Virology·Insun KimYoung-Sik Kim
Nov 19, 2019·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Mohammad Hadi Karbalaie NiyaAlireza Tabibzadeh
Apr 4, 2021·Cancers·Ivonne A Montes-MojarroLeticia Quintanilla-Martinez

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