Genomic analysis of porcine circovirus type 2 from southern China.

Veterinary Medicine and Science
Qizhuang LvYulin Zhu

Abstract

Porcine circovirus type 2 (PCV2) is recognized as virulent porcine pathogen and has been linked to porcine circovirus diseases (PCVD). However, there remain many unknowns regarding the spread and epidemic growth of PCV2. To assess the genetic diversity of PCV2 in the southern China, a total of 92 sequences of PCV2 strains from this region were retrieved from GenBank and were subjected to amino acid variation and phylogenetic analyses together with 28 representative sequences, based on the sequence of the ORF2 gene, from different swine-producing countries. All 92 PCV2 strains shared between 93.7% and 100% sequence similarity and could be divided into four genotypes (PCV2a, PCV2b, PCV2d and PCV2h), of which PCV2d had surpassed PCV2b and became the most prevalent PCV2 genotype in this region. Alignment of the deduced amino acid sequences of the capsid protein revealed that the obtained PCV2 strains possess two major heterogenic regions/hypervariable regions (positions 52-68 and 185-191), which were within or close to the epitopic regions in the capsid (Cap) protein. Meanwhile, the 92 PCV2 sequences also show evidence of at least five unique recombination events. The data in this study indicate that the PCV2 strains in the souther...Continue Reading

References

Apr 15, 2008·Molecular Biology and Evolution·Vladimir N MininMarc A Suchard
Jun 23, 2009·Virus Research·Fang WangHanchun Yang
Sep 29, 2009·Journal of Veterinary Internal Medicine·J GillespieV Buechner-Maxwell
Feb 1, 2012·Archives of Virology·Van Giap NguyenBong Kyun Park
Feb 19, 2013·Transboundary and Emerging Diseases·T M L HuynhB K Park
Jul 12, 2014·Virus Genes·Qi-Zhuang LvYan-Ming Zhang
Oct 8, 2014·Genome Announcements·Minxiu ZhangTingting Zeng
Nov 18, 2014·Expert Review of Vaccines·Joaquim Segalés
Mar 24, 2016·Molecular Biology and Evolution·Sudhir KumarKoichiro Tamura
Jun 5, 2017·Archives of Virology·Cheng-Gang JiangTong-Qing An
Sep 11, 2017·Veterinary Microbiology·Nattarat ThangthamniyomPorntippa Lekcharoensuk
Oct 1, 2017·Transboundary and Emerging Diseases·F BaoW Gong
Oct 21, 2017·The Veterinary Record·Sylvia S GriersonSusanna Williamson
Nov 19, 2017·Transboundary and Emerging Diseases·S YangJ Cai
Nov 28, 2017·Veterinary Research Communications·Dongge LiYunbo Jiang
Apr 3, 2018·PeerJ·Jiankui LiuXiaoyan Yang

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Datasets Mentioned

BETA
EF493839
MH465418
MH465430

Methods Mentioned

BETA
genotyping

Software Mentioned

DNASTAR
BootScan
RDP
GeneConv
MEGA
Recombination Detection Program ( RDP
Chimaera
Clustal W
RDP4
SiScan

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