Genomic analysis of prostate carcinoma specimens obtained via ultrasound-guided needle biopsy may be of use in preoperative decision-making

Cancer
Manuel R TeixeiraRagnhild A Lothe

Abstract

The widespread use of prostate-specific antigen (PSA) testing to screen for prostate carcinoma has led to significant overdiagnosis, due to the frequent detection of indolent malignancies on PSA screening. The detection of abnormal PSA levels typically is followed by ultrasound-guided needle biopsy. Therefore, in an effort to identify genetic markers that augment the information provided by standard histopathologic classification, the authors tested the feasibility of using these minute biopsy samples for genomic profiling via chromosome banding analysis and comparative genomic hybridization (CGH). Ultrasound-guided needle biopsy specimens obtained preoperatively from 35 patients with prostate carcinoma were analyzed via chromosome banding analysis (after short-term culturing) and CGH. The findings of these analyses then were analyzed for potential correlations with clinicopathologic parameters. Chromosome banding analysis and CGH were possible in 34 and 33 of the 35 study specimens, respectively. Combined analysis revealed aberrations in 69% of all samples investigated. Copy number losses occurred most commonly at 8p (58% of all abnormal specimens), 16q (42%), and 13q (37%), whereas the only gains detected in more than 1 speci...Continue Reading

Citations

Mar 11, 2005·Current Opinion in Obstetrics & Gynecology·Jean-Michel Lapierre, Gérard Tachdjian
Mar 22, 2014·Journal of Biomedical Science·Liang-Chuan LaiEric Y Chuang
Oct 20, 2005·Genes, Chromosomes & Cancer·Franclim R RibeiroManuel R Teixeira
Dec 13, 2005·Cancer Genetics and Cytogenetics·Nuno CerveiraManuel R Teixeira
May 10, 2012·The American Journal of Pathology·Yan P YuJian-Hua Luo
Sep 28, 2013·The American Journal of Pathology·Hongzhen LiGriffin P Rodgers
Jun 21, 2018·Genes, Chromosomes & Cancer·Martina KluthRonald Simon
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