Genomic analysis of RNA alternative splicing in cancers

Frontiers in Bioscience : a Journal and Virtual Library
Yi Xing

Abstract

Alternative splicing is an important and prevalent mechanism of gene regulation in higher eukaryotes. Nearly three quarters of human multi-exon genes are alternatively spliced. There is great interest in discovering alternative splicing events in the transcriptome of cancer cells, and in understanding how alternative splicing contributes to tumorigenesis. In this article, I will review recent advances in global analyses of pre-mRNA alternative splicing, and the applications of these genomic technologies to studies of alternative splicing in human cancers.

References

Jan 18, 2012·Biochemical Pharmacology·Scott T Eblen
Sep 8, 2011·Wiley Interdisciplinary Reviews. RNA·Anke Busch, Klemens J Hertel
Jul 25, 2009·Journal of Cellular and Molecular Medicine·Meike KörnerLaurence J Miller

Related Concepts

Nested Transcripts
Exons
Genome
Neoplasms
Genomics
Heterogeneous Nuclear RNA
Tumor Cells, Malignant
Cdna Microarrays
Malignant Neoplasms
Transcriptome

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