Genomic analysis to define molecular basis of aggressiveness in a mouse model of oral cancer

Genomics Data
Varun ChalivendraRavindra Uppaluri

Abstract

To investigate the molecular basis underlying aggressive behavior in oral squamous cell carcinoma (OSCC), our laboratory developed a carcinogen-induced mouse oral cancer (MOC) cell line model that encompasses the growth and metastasis spectrum of its human counterpart. We performed next-generation sequencing (NGS) and gene expression microarray profiles to explore the genomic and transcriptional backgrounds of the differential MOC line phenotypes, as well as, the cross-species relevance of the model. Here we describe the comparative analysis of NGS (www.ncbi.nlm.nih.gov/biosample?LinkName=bioproject_biosample_all&from_uid=247825) and expression microarray (www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE50041) data from the MOC lines and corresponding human data, as described in our recent publication [1].

References

Nov 17, 2011·Cancer Research·Nancy P JuddRavindra Uppaluri
Mar 29, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael D OnkenRavindra Uppaluri

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Citations

Aug 9, 2015·Journal of Dental Research·L K DionneX J Wang
Mar 14, 2018·Journal of Dental Research·Y S TanY L Lei
Jan 17, 2019·Journal for Immunotherapy of Cancer·Aurelie HanoteauAndrew G Sikora
Mar 2, 2021·Clinical & Translational Immunology·Silvia LonardiWilliam Vermi

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Methods Mentioned

BETA
genotyping
Chips
exome sequencing

Software Mentioned

Genome
Excel
VLOOKUP
Partek Genomics Suite
Studio
Varscan

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