Genomic and antigenic characterization of porcine epidemic diarrhoea virus strains isolated from South Korea, 2017

Transboundary and Emerging Diseases
Sunhee Lee, Changhee Lee

Abstract

Porcine epidemic diarrhoea virus (PEDV) is a globally emerging and re-emerging enteric coronavirus in pigs causing serious economic threats to the world swine industry. Since the re-emergence of massive PEDV outbreaks in South Korea in 2013-2014, domestic pig farms have continued to experience PED epidemics or endemics. This study represents the molecular characterization of PEDV isolates identified in diarrhoeic animals collected across the country in 2017. Initial sequencing analysis of the full-length S genes revealed that 70% of the 2017 isolates (7/10) belong to the G2b subgroup, while the remaining isolates were classified as G1b. The data indicated that both variant G1b and global epidemic G2b strains were responsible for current PED outbreaks in South Korea. The 2017 G1b and G2b isolates shared 98.7%-99.4% and 98.1%-99.2% amino acid sequence identity at the S gene level and 99.3% and 99.0%-99.6% nucleotide sequence homology at the genome level compared to the corresponding Korean prototype G1b and G2b strains, respectively. In an interesting manner, one G2b-like KNU-1705 strain was found to possess a large 39-nucleotide deletion in the ORF1a region theoretically encoding nonstructural protein 3. Phylogenetic analysis ba...Continue Reading

References

Jan 1, 1978·Archives of Virology·M B Pensaert, P de Bouck
Dec 1, 1983·Nihon juigaku zasshi. The Japanese journal of veterinary science·K TakahashiK Ohshima
Mar 1, 2006·Virus Research·Alexander E GorbalenyaEric J Snijder
May 10, 2007·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Jun 29, 2007·Archives of Virology·Y-S ChungC Kang
Jul 25, 2009·Emerging Infectious Diseases·Suphasawatt PuranavejaRoongroje Thanawongnuwech
May 18, 2011·European Journal of Applied Physiology·Rachel G ArmstrongGlen P Kenny
Jun 29, 2013·Archives of Virology·Yu Na Lee, Changhee Lee
Jul 28, 2013·Nature·Beth Mole
Aug 22, 2013·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Gregory W StevensonKyoungjin J Yoon
Jun 6, 2014·The Journal of Veterinary Medical Science·Chao-Nan LinMing-Tang Chiou
Jun 25, 2014·Emerging Infectious Diseases·Sunhee Lee, Changhee Lee
Aug 20, 2014·The Veterinary Journal·Priscilla F GerberTanja Opriessnig
Oct 4, 2014·Emerging Infectious Diseases·Anastasia N VlasovaLinda J Saif
Feb 11, 2015·Archives of Virology·Seong-Hee KimKyoung-Ki Lee
May 18, 2016·Veterinary Immunology and Immunopathology·Pil-Soo BaekChanghee Lee
Nov 13, 2017·Antiviral Research·Jian LeiRolf Hilgenfeld

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