Genomic and clinical characterization of pulmonary-only metastatic prostate cancer: A unique molecular subtype

The Prostate
Eugene ShenderovEmmanuel S Antonarakis

Abstract

Isolated pulmonary involvement is uncommon in metastatic hormone-sensitive prostate cancer (mHSPC). To characterize outcomes and molecular alterations of this unique patient subset, we conducted a retrospective review of patients with hormone-naïve prostate cancer presenting with lung-only metastases. This was a retrospective single-institution study. Medical records of 25 patients presenting with pulmonary-only metastases before receiving androgen deprivation therapy (ADT) were analyzed. Germline and/or somatic genomic results, where available (n = 16), were documented. Tumor tissue was analyzed using clinical-grade next-generation DNA sequencing assays. Clinical endpoints included complete prostate-specific antigen (PSA) response to ADT (<0.1 ng/mL), median overall survival (OS) from time of ADT initiation, median PSA progression-free survival (PSA-PFS), and failure-free survival (FFS) at 4 years. Baseline characteristics were notable for 48% of men (12 of 25) having first or second-degree relatives with prostate cancer, compared with 20% expected. Complete PSA responses to ADT were noted in 52% of men, with a median PSA-PFS of 66 months, a 4-year FFS rate of 72%, and a median OS that was not reached after 190 months. In eval...Continue Reading

References

Jun 1, 1995·Cancer·S J FabozziA M el-Mahdi
Nov 24, 1999·The Journal of Urology·C P SmithD Kadmon
Jun 3, 2000·Human Pathology·L BubendorfM J Mihatsch
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Apr 4, 2013·Science Signaling·Jianjiong GaoNikolaus Schultz
Sep 26, 2014·Nature Communications·Colin C PritchardPeter S Nelson
May 23, 2015·Cell·Dan RobinsonArul M Chinnaiyan
Aug 6, 2015·The New England Journal of Medicine·Christopher J SweeneyRobert S DiPaola
Nov 7, 2015·Cell·UNKNOWN Cancer Genome Atlas Research Network
Nov 20, 2015·Nucleic Acids Research·Melissa J LandrumDonna R Maglott
Feb 24, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Howard I ScherUNKNOWN Prostate Cancer Clinical Trials Working Group 3
Jun 6, 2017·The New England Journal of Medicine·Karim FizaziUNKNOWN LATITUDE Investigators
Jun 6, 2017·The New England Journal of Medicine·Nicholas D JamesUNKNOWN STAMPEDE Investigators
Aug 10, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Liana B GuedesTamara L Lotan
Oct 26, 2018·Lancet·Christopher C ParkerUNKNOWN Systemic Therapy for Advanced or Metastatic Prostate cancer: Evaluation of Drug Efficacy (STAMPEDE) investigators

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