Genomic and linguistic affinities: a study of allelic and haplotype diversity at DRD2 locus among the tribes of Gujarat, western India

Genetic Testing and Molecular Biomarkers
Gautam K KshatriyaPradeep K Ghosh

Abstract

Do genetic and linguistic affinities necessarily go hand in hand? An attempt has been made in the present work to explore this dimension of population structure using three evolutionarily important TaqI sites (TaqI A, TaqI B, and TaqI D) on the dopamine receptor D2 (DRD2) locus. For the first time, DNA samples from 612 unrelated individuals belonging to 11 Indo-European-speaking tribal population groups of Gujarat, western India, have been analyzed for these three sites. All the three sites are found to be polymorphic with greater interpopulation variation seen at the TaqI B site. The average heterozygosity for the haplotype system has been found to be high in the populations under study. Most of the populations share six of the eight haplotypes pointing toward underlying genetic uniformity, which is further reaffirmed by regression analysis of heterozygosity on genetic distance. The frequency of ancestral haplotype B2D2A1 is found to range between 1.9% and 15.9%. Linkage disequilibrium between TaqI B and TaqI D sites and between TaqI B and TaqI A sites is statistically significant in all but one population. Our findings reveal strong affinities between Indo-European-speaking tribal groups of Gujarat and Dravidian-speaking trib...Continue Reading

References

Dec 25, 1991·Nucleic Acids Research·A ParsianR D Todd
Apr 18, 1990·JAMA : the Journal of the American Medical Association·K BlumJ B Cohn
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Dec 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·M Nei
Mar 31, 1994·Nature·A M BowcockL L Cavalli-Sforza
Oct 1, 1993·Drug and Alcohol Dependence·E P NobleM D Anglin
Jun 1, 1996·Alcoholism, Clinical and Experimental Research·K K KiddB Bonne-Tamir
Sep 19, 2000·DNA Sequence : the Journal of DNA Sequencing and Mapping·S IyengarK K Kidd
May 31, 2001·Genome Research·M BamshadL B Jorde
Jan 10, 2002·Journal of Biosciences·P P Majumder
Jan 22, 2003·American Journal of Human Genetics·T KivisildR Villems
Oct 4, 2003·Genome Research·Analabha BasuPartha P Majumder
Oct 29, 2005·Nature·UNKNOWN International HapMap Consortium
Aug 10, 2006·PLoS Genetics·Vincent Plagnol, Jeffrey D Wall
Mar 25, 2009·Genetic Testing and Molecular Biomarkers·Kallur Nava SaraswathyAloke Kumar Kalla
Oct 21, 2009·Genetic Testing and Molecular Biomarkers·Kallur N SaraswathyMohinder P Sachdeva

❮ Previous
Next ❯

Software Mentioned

HAPLOPOP
DeclareMathSizes

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.