Genomic approaches in acute leukemia

Best Practice & Research. Clinical Haematology
Kimberly Stegmaier

Abstract

The application of expression-based genomic approaches to medical research is traced here, particularly as they relate to hematologic malignancy. DNA microarray technology and its role in the refinement of the taxonomy of disease, the development of models of outcome prediction, and the identification of therapeutic targets are discussed. Particular attention is given to the exploration of a signature-based screening approach, which bypasses the need to have a priori knowledge of the target.

References

Dec 4, 2001·Nature Genetics·Scott A ArmstrongStanley J Korsmeyer
Jul 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·Claudia SchochTorsten Haferlach
Dec 13, 2003·Blood·Scott A ArmstrongStanley J Korsmeyer
Apr 16, 2004·The New England Journal of Medicine·Lars BullingerJonathan R Pollack
Apr 16, 2004·The New England Journal of Medicine·Peter J M ValkRuud Delwel
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Citations

Feb 14, 2014·Leukemia Research·Daniel J DeangeloRichard M Stone
Jul 1, 2008·Hematology/oncology and Stem Cell Therapy·Syed Z ZaidiMahmoud Aljurf
Sep 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Branimir I SikicNorman J Lacayo

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