Genomic Biomarkers for the Prediction of Stage and Prognosis of Upper Tract Urothelial Carcinoma

The Journal of Urology
Aditya BagrodiaCollaborators

Abstract

Genomic characterization of radical nephroureterectomy specimens in patients with upper tract urothelial carcinoma may allow for thoughtful integration of systemic and targeted therapies. We sought to determine whether genomic alterations in upper tract urothelial carcinoma are associated with adverse pathological and clinical outcomes. Next generation exon capture sequencing of 300 cancer associated genes was performed in 83 patients with upper tract urothelial carcinoma. Genomic alterations were assessed individually and also grouped into core signal transduction pathways or canonical cell functions for association with clinicopathological outcomes. Binary outcomes, including grade (high vs low), T stage (pTa/T1/T2 vs pT3/T4) and organ confined status (pT2 or less and N0/Nx vs greater than pT2 or N+) were assessed with the Kruskal-Wallis and Fisher exact tests as appropriate. Associations between alterations and survival were estimated using the Kaplan-Meier method and Cox regression. Of the 24 most commonly altered genes in 9 pathways TP53/MDM2 alterations and FGFR3 mutations were the only 2 alterations uniformly associated with high grade, advanced stage, nonorgan confined disease, and recurrence-free and cancer specific su...Continue Reading

References

Jul 1, 1993·Genes & Development·X WuA J Levine
Aug 20, 2005·Nature Reviews. Cancer·Xue-Ru Wu
Jul 26, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·UNKNOWN International Bladder Cancer Nomogram ConsortiumKinjal C Vora
Jan 22, 2009·Cancer·Vitaly MargulisUNKNOWN Upper Tract Urothelial Carcinoma CollaborationThe Upper Tract Urothelial Carcinoma Collaboration
Jun 22, 2010·Cancer·Claudio JeldresPierre I Karakiewicz
Jul 14, 2010·The Journal of Urology·Vitaly MargulisUNKNOWN Upper Tract Urothelial Carcinoma Collaborative Group
Jul 31, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gopa IyerDavid B Solit
Jan 31, 2014·Nature·UNKNOWN Cancer Genome Atlas Research Network
Dec 24, 2014·Nature Reviews. Cancer·Margaret A Knowles, Carolyn D Hurst
Aug 19, 2015·European Urology·John P SfakianosJonathan A Coleman

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Citations

May 8, 2016·Current Urology Reports·Jennifer Gordetsky, Jessica Zarzour
Apr 5, 2019·World Journal of Urology·Mudhar N HasanMarianne Brehmer
Sep 2, 2016·Current Opinion in Urology·Solene-Florence Kammerer-JacquetKarim Bensalah
Feb 9, 2017·Nature Reviews. Urology·Alexander P GlaserJoshua J Meeks
Jan 24, 2019·Therapeutic Advances in Urology·Maristella BianconiRodolfo Montironi
Mar 28, 2019·World Journal of Urology·Grzegorz FojeckiMarianne Brehmer
Aug 15, 2020·Journal of the American Society of Cytopathology : JASC·M Lisa ZhangPoonam Vohra
Mar 7, 2021·Genes·Elisa De LorenzisEmanuele Montanari
Nov 14, 2021·Current Opinion in Urology·Florian Berndl, Melanie R Hassler

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