Abstract
This study investigated the prognostic effects of genomic biomarkers for predicting chemoradiotherapy (CRT)-based treatment outcomes in patients with adenocarcinoma (AC) of the uterine cervix. In all, 21 patients receiving definitive CRT were included. In accordance with the International Federation of Gynecology and Obstetrics (FIGO) staging system, 5, 8, and 8 patients were classified as having stage IB3, II, and III disease, respectively. Pretreatment biomarkers were analyzed using tissue microarrays from biopsy specimens. Genomic alterations were examined by next-generation sequencing (NGS). The outcome endpoints were disease-free survival (DFS), distant metastasis-free survival (DMFS), and local relapse-free survival (LRFS). A Cox regression model was used to examine the prognostic effects of the biomarkers and clinical parameters. The presence of myeloid cell leukemia-1 (MCL1) gene amplification and a lower immunohistochemical (IHC) marker of tumor necrotic factor alpha (TNF-α) H-score were two prognostic factors for inferior DFS. The four-year DFS was 28% and 68% for patients with or without MCL1 copy number gain, respectively (p = 0.028). In addition, MCL1 amplification predicted poor DMFS. A lower tumor mutation number...Continue Reading
References
Oct 1, 1995·Gynecologic Oncology·P J EifelT L Smith
Jun 7, 1995·Journal of the National Cancer Institute·F X BoschK V Shah
Aug 6, 2000·Gynecologic Oncology·H O SmithC R Key
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·C.-H. LaiJ.-D. Lin
Dec 12, 2003·Nature·Joseph T OpfermanStanley J Korsmeyer
Aug 12, 2004·Acta Oncologica·Marianne Nordsmark, Jens Overgaard
Dec 8, 2004·Gynecologic Oncology·Stephen A ContagEric S Calhoun
Feb 8, 2005·Molecular Cell·Lin ChenDavid C S Huang
Jan 13, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Richard PötterUNKNOWN GEC ESTRO Working Group
Mar 2, 2006·Journal of the National Cancer Institute·Xavier CastellsaguéUNKNOWN International Agency for Research on Cancer Multicenter Cervical Cancer Study Group
Dec 21, 2006·Cancer Research·Bin YanChuan-Yuan Li
Aug 19, 2009·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Kingshuk Roy ChoudhuryJoseph G Rajendran
Nov 3, 2009·Gynecologic Oncology·Lilian T GienGillian Thomas
May 7, 2010·Japanese Journal of Clinical Oncology·Yuzuru NiibeKazushige Hayakawa
Jun 15, 2010·FEBS Letters·Luke W ThomasSteven W Edwards
Jun 15, 2010·International Journal of Radiation Oncology, Biology, Physics·Yi-Ting HuangJi-Hong Hong
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Mar 4, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter G RosePaul A DiSilvestro
Oct 5, 2015·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Adriana BermudezEric Leung
Jun 23, 2016·Applied Immunohistochemistry & Molecular Morphology : AIMM·Charlotte RoachKarina Kulangara
Jun 28, 2016·Cytokine·Shyama PalBhavani S Shankar
Jul 22, 2016·Cancer Immunology Research·Mariko IshibashiKoiti Inokuchi
Jan 24, 2017·Nature·UNKNOWN Cancer Genome Atlas Research NetworkUNKNOWN Washington University in St Louis
Aug 10, 2018·Scientific Reports·Shang-Wen ChenChia-Hung Kao
Nov 15, 2018·OncoTargets and Therapy·Weiguo XiangLongchuan Bai
Dec 19, 2018·Radiation Oncology·Ke HuFuquan Zhang
Jun 10, 2019·Anticancer Research·Ying-Chun LinShang-Wen Chen
Jul 17, 2019·Journal for Immunotherapy of Cancer·Laura FancelloLuca Mazzarella