Genomic boundaries between human populations

Human Heredity
G Barbujani, Elise M S Belle

Abstract

Different authors disagree on whether human genome variation should be described as continuous or discontinuous; in the latter case, by attributing an individual's genotype to one genetic cluster, one would also obtain information on the individual's genome in general. An analysis of 377 microsatellites of the CEPH human diversity panel was interpreted as evidence that most genotypes cluster into one of five distinct groups, approximately corresponding to continents, which were pro- posed by some authors as the major biological subdivisions of humankind. Here we analyse the same dataset by a specific numerical method, designed to detect genomic boundaries, i.e. zones of increased change in maps of genomic variation. We show that statistically significant boundaries can be described between groups of populations, but different clusters are identified, depending on the assumptions of the model. In addition, these clusters do not correspond to the clusters inferred from previous analyses of the same or of other polymorphisms. We conclude that it is indeed possible to cluster genotypes according to geography, but no study so far identified unambiguously anything that can be regarded as a major genetic subdivision of humankind, and ...Continue Reading

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Citations

May 20, 2009·Journal of Health Politics, Policy and Law·Vence L BonhamLeonard M Fleck
Feb 18, 2016·Journal of Biosocial Science·Alejandra ToledoAntonio González-Martin
May 18, 2010·Trends in Genetics : TIG·Guido Barbujani, Vincenza Colonna
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May 6, 2015·Investigative Genetics·Andreas Wollstein, Oscar Lao
Mar 27, 2018·American Journal of Physical Anthropology·Rachel Caspari
Mar 16, 2007·European Journal of Human Genetics : EJHG·Bryndis Yngvadottir
May 18, 2007·American Journal of Physical Anthropology·Elise M S Belle, Guido Barbujani
Apr 4, 2013·G3 : Genes - Genomes - Genetics·Trevor J PembertonNoah A Rosenberg
Nov 26, 2009·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Sébastien Rioux Paquette, François-Joseph Lapointe

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