Genomic characterization of a testis-specific TFIIS (TCEA2) gene

Genomics
Z A Weaver, C M Kane

Abstract

There is a family of genes encoding TFIIS-related proteins in human cells. We have focused upon the genomic organization of one family member expressed primarily in the testis. This gene encodes a transcription elongation factor similar to but distinct from that encoded by a previously reported TFIIS gene. Also in contrast to the previously reported TFIIS gene, the testis gene contains introns. All exon-intron junction sequences match the consensus GT/AG rule. The gene consists of seven exons and six introns with a total size of approximately 7 kb. The nucleotide sequence of the 5 flanking region of the testis TFIIS gene contains several potential regulatory factor-binding sites, not all of which are present in the TFIIS gene, whose expression is nearly ubiquitous. Elucidation of the full structure of the testis TFIIS gene should be useful for determining its chromosomal localization and its potential role in the regulation of gene expression in human tissues.

References

Jan 1, 1981·Annual Review of Biochemistry·R Breathnach, P Chambon
Nov 21, 1995·Biochemistry·G Cipres-Palacin, C M Kane
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·G Cipres-Palacin, C M Kane
Jul 1, 1996·Current Biology : CB·E E Schmidt

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Citations

Mar 21, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M Wind, D Reines
Jul 27, 2000·Molecular and Cellular Biology·J K Davie, C M Kane
Jan 20, 2009·Journal of Molecular Biology·Marion GrasserKlaus D Grasser
Aug 12, 2008·Fertility and Sterility·Tadahiro Yasuo, Kotaro Kitaya
Aug 15, 2000·The Journal of Biological Chemistry·N B Shimasaki, C M Kane
Sep 6, 2002·Biochimica Et Biophysica Acta·Rachel N Fish, Caroline M Kane

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