Genomic Characterization of Enterobacter cloacae Isolates from China That Coproduce KPC-3 and NDM-1 Carbapenemases

Antimicrobial Agents and Chemotherapy
Hong DuBarry N Kreiswirth

Abstract

Here, we report twoEnterobacter cloacaesequence type 231 isolates coproducing KPC-3 and NDM-1 that have caused lethal infections in a tertiary hospital in China. TheblaNDM-1-harboring plasmids carry IncA/C2and IncR replicons, showing a mosaic plasmid structure, and theblaNDM-1is harbored on a novel class I integron-like element.blaKPC-3is located on a Tn3-ΔblaTEM-1-blaKPC-3-ΔTn1722element, flanked by two 9-bp direct-repeat sequences and harbored on an IncX6 plasmid.

References

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Citations

Mar 8, 2017·Plasmid·Paula Bustamante, Jonathan R Iredell
Jan 26, 2018·The Journal of Antimicrobial Chemotherapy·M RozwandowiczJ Hordijk
Apr 26, 2017·Antimicrobial Agents and Chemotherapy·Qinglan GuoMinggui Wang
Aug 31, 2019·Annals of the New York Academy of Sciences·Katlego KopotsaNontombi Marylucy Mbelle
Aug 3, 2018·Clinical Microbiology Reviews·Sally R PartridgeSlade O Jensen
Feb 28, 2020·Clinical Microbiology Reviews·Karen Bush, Patricia A Bradford
Sep 5, 2019·Frontiers in Microbiology·Xiaoyan CuiHong Du
Nov 18, 2020·International Journal of Molecular Sciences·Corneliu Ovidiu VrancianuMariana Carmen Chifiriuc
Jun 14, 2021·Microbial Pathogenesis·Hafiz Iftikhar HussainKun Li
Jul 8, 2021·International Microbiology : the Official Journal of the Spanish Society for Microbiology·Xiaokun WangQingxia Xu

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