Genomic characterization of recurrent mold infections in thoracic transplant recipients

Transplant Infectious Disease : an Official Journal of the Transplantation Society
Julia A MessinaJohn R Perfect

Abstract

Invasive mold disease in thoracic organ transplant recipients is a well-recognized complication, but the long-term persistence of molds within the human body and evasion of host defenses has not been well-described. We present 2 cases of invasive mold disease (Verruconis gallopava and Aspergillus fumigatus) in thoracic transplant recipients who had the same mold cultured years prior to the invasive disease presentation. The paired isolates from the index and recurrent infections in both patients were compared using whole-genome sequencing to determine if the same strain of mold caused both the index and recurrent infections. In Case 1, the isolates were found to be of the same strain indicating that the initial colonizing isolate identified pre-transplant eventually caused invasive mold disease post-transplant while in Case 2, the 2 isolates were not of the same strain. These results demonstrate the distinct possibility of molds both persisting within the human body for years prior to invasive mold disease or the long-term risk of recurrent, persistent infection with more than one strain. Further studies of long-term molecular epidemiology of IMD and risk factors for mold persistence in transplant recipients are encouraged.

References

Sep 21, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R M Donlan
Apr 7, 2004·Mayo Clinic Proceedings·Rachel J CookJay H Ryu
Aug 20, 2008·Antimicrobial Agents and Chemotherapy·Marc J SeidlerFrank-Michael C Müller
Jul 25, 2009·Emerging Infectious Diseases·Susan J HowardDavid W Denning
Jan 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·N SinghUNKNOWN AST Infectious Diseases Community of Practice
Oct 1, 2011·Clinical Transplantation·Zubair A QureshiFernanda P Silveira
Feb 25, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Patricia MuñozEmilio Bouza
Apr 15, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C T DoligalskiB D Alexander
May 8, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jose F Camargo, Shahid Husain
May 23, 2014·Proceedings of the National Academy of Sciences of the United States of America·Yuan O ZhuDmitri A Petrov
Sep 19, 2014·Journal of Clinical Microbiology·Daisuke HagiwaraTohru Gonoi
Aug 8, 2015·The American Journal of Case Reports·Archana Kodali, Koroush Khalighi
Oct 27, 2015·Cell·Avihu H YonaYitzhak Pilpel
Oct 30, 2016·The Lancet Infectious Diseases·Paul E VerweijWillem J G Melchers
Nov 5, 2016·Frontiers in Cellular and Infection Microbiology·Pedro PaisMiguel C Teixeira
Jan 26, 2017·Nature Microbiology·Jean-Paul Latgé

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Citations

Jun 11, 2021·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Pooja GandhiBrendan R Jackson

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