Genomic characterization of seven distinct bat coronaviruses in Kenya.

Virus Research
Ying TaoSuxiang Tong

Abstract

To better understand the genetic diversity and genomic features of 41 coronaviruses (CoVs) identified from Kenya bats in 2006, seven CoVs as representatives of seven different phylogenetic groups identified from partial polymerase gene sequences, were subjected to extensive genomic sequencing. As a result, 15-16kb nucleotide sequences encoding complete RNA dependent RNA polymerase, spike, envelope, membrane, and nucleocapsid proteins plus other open reading frames (ORFs) were generated. Sequences analysis confirmed that the CoVs from Kenya bats are divergent members of Alphacoronavirus and Betacoronavirus genera. Furthermore, the CoVs BtKY22, BtKY41, and BtKY43 in Alphacoronavirus genus and BtKY24 in Betacoronavirus genus are likely representatives of 4 novel CoV species. BtKY27 and BtKY33 are members of the established bat CoV species in Alphacoronavirus genus and BtKY06 is a member of the established bat CoV species in Betacoronavirus genus. The genome organization of these seven CoVs is similar to other known CoVs from the same groups except for differences in the number of putative ORFs following the N gene. The present results confirm a significant diversity of CoVs circulating in Kenya bats. These Kenya bat CoVs are phylo...Continue Reading

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Citations

Nov 5, 2013·Antiviral Research·Jan Felix DrexlerChristian Drosten
Apr 14, 2015·Expert Review of Vaccines·Amy B PapaneriJens H Kuhn
Aug 7, 2013·Science China. Life Sciences·ZhengLi Shi
Aug 14, 2013·The Journal of General Virology·Rebekah C KadingBarry R Miller
Apr 18, 2015·Virology Journal·Supaporn WacharapluesadeeThiravat Hemachudha
Apr 19, 2015·Virology Journal·Norosoa H RazanajatovoJean-Michel Heraud
Sep 18, 2015·Journal of Virology·Victor Max CormanJan Felix Drexler
May 31, 2020·Transboundary and Emerging Diseases·Van Thi LoHye Kwon Kim
Dec 8, 2019·EcoHealth·Julius NzizaKirsten Gilardi
Jun 6, 2017·Protein Science : a Publication of the Protein Society·Robert G HammondMargaret A Johnson

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Methods Mentioned

BETA
PCR

Software Mentioned

Chimaera
Geneconv
RDP
BLAST
MUSCLE
Sequencher
MEGA
MaxChi
NetNGlyc

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