Genomic characterization of severe acute respiratory syndrome-related coronavirus in European bats and classification of coronaviruses based on partial RNA-dependent RNA polymerase gene sequences.

Journal of Virology
Jan Felix DrexlerChristian Drosten


Bats may host emerging viruses, including coronaviruses (CoV). We conducted an evaluation of CoV in rhinolophid and vespertilionid bat species common in Europe. Rhinolophids carried severe acute respiratory syndrome (SARS)-related CoV at high frequencies and concentrations (26% of animals are positive; up to 2.4×10(8) copies per gram of feces), as well as two Alphacoronavirus clades, one novel and one related to the HKU2 clade. All three clades present in Miniopterus bats in China (HKU7, HKU8, and 1A related) were also present in European Miniopterus bats. An additional novel Alphacoronavirus clade (bat CoV [BtCoV]/BNM98-30) was detected in Nyctalus leisleri. A CoV grouping criterion was developed by comparing amino acid identities across an 816-bp fragment of the RNA-dependent RNA polymerases (RdRp) of all accepted mammalian CoV species (RdRp-based grouping units [RGU]). Criteria for defining separate RGU in mammalian CoV were a >4.8% amino acid distance for alphacoronaviruses and a >6.3% distance for betacoronaviruses. All the above-mentioned novel clades represented independent RGU. Strict associations between CoV RGU and host bat genera were confirmed for six independent RGU represented simultaneously in China and Europe. A...Continue Reading


Jan 1, 1980·Journal of Medical Virology·H E LarsonD A Tyrrell
Jul 1, 1983·Archives of Disease in Childhood·D IsaacsM R MacNaughton
Dec 1, 1996·Statistical Methods in Medical Research·A Gelman, D B Rubin
Jul 19, 2000·The Journal of General Virology·K HalpinJ S Mackenzie
Jun 1, 2001·Emerging Infectious Diseases·J M YobT Ksiazek
Apr 10, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Astrid VabretFrançois Freymuth
Apr 12, 2003·The New England Journal of Medicine·Christian DrostenHans Wilhelm Doerr
Aug 13, 2003·Bioinformatics·Fredrik Ronquist, John P Huelsenbeck
Oct 28, 2003·Archives of Virology·J M GonzálezLuis Enjuanes
Dec 4, 2003·Science·Markus EickmannRino Rappuoli
Dec 19, 2003·The New England Journal of Medicine·Joseph S M PeirisKlaus Stöhr
Jan 31, 2004·Science·UNKNOWN Chinese SARS Molecular Epidemiology Consortium
Oct 27, 2004·Emerging Infectious Diseases·Guodong LiangUNKNOWN SARS Diagnosis Working Group
Feb 1, 2005·Journal of Virology·L L M PoonJ S M Peiris
Feb 8, 2005·Proceedings of the National Academy of Sciences of the United States of America·Huai-Dong SongGuo-Ping Zhao
Jun 7, 2005·Journal of Virological Methods·Christine Uhlenhaut, Maren Kracht
Sep 20, 2005·Proceedings of the National Academy of Sciences of the United States of America·Susanna K P LauKwok-Yung Yuen
Oct 1, 2005·Science·Wendong LiLin-Fa Wang
Dec 2, 2005·Nature·Eric M LeroyRobert Swanepoel
May 2, 2006·Virology·Patrick C Y WooKwok-yung Yuen
Jul 15, 2006·Journal of Virology·X C TangY Guan
Jul 19, 2006·Clinical Microbiology Reviews·Charles H CalisherTony Schountz
Aug 1, 2006·Advances in Virus Research·Paul S Masters
Aug 17, 2006·Journal of Virology·Marie-Pierre EgloffBruno Canard
Oct 14, 2006·Advances in Experimental Medicine and Biology·Christel Schwegmann-WesselsGeorg Herrler
Feb 3, 2007·Journal of Virology·D VijaykrishnaY Guan
May 10, 2007·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Nov 13, 2007·BMC Evolutionary Biology·Alexei J Drummond, Andrew Rambaut
Nov 15, 2007·Journal of Paediatrics and Child Health·Astrid VabretFrançois Freymuth
Nov 23, 2007·Critical Reviews in Microbiology·Louis H Nel, Wanda Markotter
Feb 9, 2008·Emerging Infectious Diseases·Robert SwanepoelUNKNOWN International Scientific and Technical Committee for Marburg Hemorrhagic Fever Control in the Democratic Republic of Congo
Feb 26, 2008·Journal of Virological Methods·Julie L ForsterSamuel J McCullough
Apr 11, 2008·Emerging Infectious Diseases·Florian Gloza-RauschChristian Drosten

❮ Previous
Next ❯


Jul 19, 2011·Archives of Virology·Ana FalcónJuan E Echevarría
Jul 6, 2013·Virus Genes·Francisco Esmaile de Sales LimaAna Cláudia Franco
Nov 5, 2013·Antiviral Research·Jan Felix DrexlerChristian Drosten
Mar 12, 2013·Vector Borne and Zoonotic Diseases·Marike GeldenhuysWanda Markotter
Oct 28, 2011·Journal of Virology·Susanna K P LauKwok-Yung Yuen
Jul 19, 2011·Future Virology·Dale L Barnard, Yohichi Kumaki
Mar 12, 2011·Emerging Infectious Diseases·Jan Felix DrexlerChristian Drosten
Apr 30, 2013·Emerging Infectious Diseases·Augustina AnnanJan Felix Drexler
Sep 21, 2013·Emerging Infectious Diseases·Ndapewa Laudika ItheteWolfgang Preiser
Nov 5, 2013·Viruses·Davide LelliMaria B Boniotti
Nov 19, 2013·Virus Genes·Paola De BenedictisGiovanni Cattoli
Mar 25, 2014·Emerging Infectious Diseases·Benjamin MeyerChristian Drosten
Jul 23, 2014·Travel Medicine and Infectious Disease·Jaffar A Al-TawfiqZiad A Memish
Aug 16, 2014·Viruses·Claudia Kohl, Andreas Kurth
Mar 16, 2013·Current Opinion in Virology·John S Mackenzie, Martyn Jeggo
May 9, 2012·Virus Research·Ying TaoSuxiang Tong
Dec 20, 2011·Current Opinion in Virology·Meagan BollesRalph Baric
Aug 7, 2013·Science China. Life Sciences·ZhengLi Shi
Dec 23, 2015·Virology Journal·Ben HuZhengli Shi
Apr 23, 2016·Viruses·Theocharis TsoleridisC Patrick McClure
Jun 8, 2014·The Journal of General Virology·Susanna K P LauKwok-Yung Yuen
Jun 14, 2013·The Journal of General Virology·Victor Max CormanJan Felix Drexler
Nov 30, 2014·Molecular Biology and Evolution·Nicole M FoleyEmma C Teeling
Apr 18, 2015·Virology Journal·Supaporn WacharapluesadeeThiravat Hemachudha
Apr 19, 2015·Virology Journal·Norosoa H RazanajatovoJean-Michel Heraud
Jul 19, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Meriadeg Ar GouilhJean-Claude Manuguerra

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved