Genomic characterization of the European sea bass Dicentrarchus labrax reveals the presence of a novel uncoupling protein (UCP) gene family member in the teleost fish lineage.

BMC Evolutionary Biology
Mbaye TineRichard Reinhardt

Abstract

Uncoupling proteins (UCP) are evolutionary conserved mitochondrial carriers that control energy metabolism and therefore play important roles in several physiological processes such as thermogenesis, regulation of reactive oxygen species (ROS), growth control, lipid metabolism and regulation of insulin secretion. Despite their importance in various physiological processes, their molecular function remains controversial. The evolution and phylogenetic distribution may assist to identify their general biological function and structure-function relationships. The exact number of uncoupling protein genes in the fish genome and their evolution is unresolved. Here we report the first characterisation of UCP gene family members in sea bass, Dicentrarchus labrax, and then retrace the evolution of the protein family in vertebrates. Four UCP genes that are shared by five other fish species were identified in sea bass genome. Phylogenetic reconstitution among vertebrate species and synteny analysis revealed that UCP1, UCP2 and UCP3 evolved from duplication events that occurred in the common ancestor of vertebrates, whereas the novel fourth UCP originated specifically in the teleost lineage. Functional divergence analysis among teleost spe...Continue Reading

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Citations

Jul 5, 2013·Proceedings. Biological Sciences·Menno P GerkemaRoelof A Hut
Apr 24, 2013·Journal of Bioenergetics and Biomembranes·Reinaldo Sousa dos SantosWagner Seixas da-Silva
Apr 5, 2013·Annals of the New York Academy of Sciences·Stuart A NewmanAlexander V Badyaev
May 15, 2015·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·R OelkrugM Jastroch
Apr 2, 2015·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Zheng-Yong WenYa-Xiong Tao
Apr 17, 2012·Developmental and Comparative Immunology·Lv-yun ZhuJian-zhong Shao
Oct 26, 2018·The Journal of Experimental Biology·Heather J BryantPatricia M Schulte

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Datasets Mentioned

BETA
ABR10900

Software Mentioned

Game
ClustalW
sim4
GENSCAN
DIVERGE
APOLLO
Datamonkey
PhyML
BLASTP
BLAST

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