Genomic clustering within functionally related gene families in Ascomycota fungi

Computational and Structural Biotechnology Journal
Danielle HageeJames T Arnone

Abstract

Multiple mechanisms collaborate for proper regulation of gene expression. One layer of this regulation is through the clustering of functionally related genes at discrete loci throughout the genome. This phenomenon occurs extensively throughout Ascomycota fungi and is an organizing principle for many gene families whose proteins participate in diverse molecular functions throughout the cell. Members of this phylum include organisms that serve as model systems and those of interest medically, pharmaceutically, and for industrial and biotechnological applications. In this review, we discuss the prevalence of functional clustering through a broad range of organisms within the phylum. Position effects on transcription, genomic locations of clusters, transcriptional regulation of clusters, and selective pressures contributing to the formation and maintenance of clusters are addressed, as are common methods to identify and characterize clusters.

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Citations

Feb 25, 2021·MSystems·Baojun Wu, Murray P Cox
Jul 10, 2021·Biochemical Society Transactions·David ShoreBenjamin Albert
Aug 12, 2021·Trends in Genetics : TIG·Oriana Q H ZinaniErtuğrul M Özbudak

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Methods Mentioned

BETA
light microscopy
deamination
dissection
genetic modifications

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