Genomic comparison of PE and PPE genes in the Mycobacterium avium complex.

Journal of Clinical Microbiology
Nick MackenzieJeroen De Buck

Abstract

The Mycobacterium avium complex (MAC) comprises genomically similar but phenotypically divergent bacteria that inhabit diverse environments and that cause disease in different hosts. In this study, a whole-genome approach was used to examine the polymorphic PE (Pro-Glu) and PPE (Pro-Pro-Glu) gene families, implicated in immunostimulation and virulence. The four major groups of MAC organisms were examined, including the newly sequenced type strains of M. intracellulare and M. avium subsp. avium, plus M. avium subsp. paratuberculosis and M. avium subsp. hominissuis, for the purpose of finding genetic differences that could be exploited to design diagnostic tests specific to these groups and that could help explain their divergence in pathogenesis and host specificity. Unique and missing PPE genes were found in all MAC members except M. avium subsp. avium. Only M. intracellulare had a unique PE gene. Apart from this, most PE and PPE sequences were conserved, with average nucleotide sequence identities of 99.1 and 98.1%, respectively, among the M. avium subspecies, but only 82.9 and 79.7% identities with the PE and PPE sequences of M. intracellulare, respectively. A detailed analysis of the amino acid sequences was performed betwee...Continue Reading

References

May 1, 1992·Research in Microbiology·R J CokerJ N Weber
Nov 1, 1991·The Journal of Infectious Diseases·M A JacobsonM A Sande
May 9, 1991·The New England Journal of Medicine·C R Horsburgh
Oct 1, 1989·Clinical Microbiology Reviews·F M Collins
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·D M CollinsW R Jacobs
Jul 1, 1993·Clinical Microbiology Reviews·C B InderliedL E Bermudez
May 1, 1993·Journal of Bacteriology·R Frothingham, K H Wilson
Jul 1, 1996·The Veterinary Clinics of North America. Food Animal Practice·R W Sweeney
Apr 1, 1996·Clinical Microbiology Reviews·J O Falkinham
Dec 10, 1999·Microbiology·X PuyangD Y Kunimoto
May 1, 2002·Journal of Clinical Microbiology·Karen StevensonJ Michael Sharp
May 15, 2002·FEMS Microbiology Letters·Stina EnglundKarl Erik Johansson
Sep 10, 2002·Journal of Bacteriology·R D FleischmannC M Fraser
Oct 24, 2003·Infection and Immunity·Rakesh Kumar ChoudharySeyed E Hasnain
Aug 6, 2005·Journal of Clinical Microbiology·Makeda SemretMarcel A Behr
Aug 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·Lingling LiVivek Kapur
Feb 4, 2006·Journal of Clinical Microbiology·Christine Y TurenneMarcel A Behr
Apr 13, 2007·Clinical Microbiology Reviews·Christine Y TurenneMarcel A Behr

❮ Previous
Next ❯

Citations

Jul 27, 2010·Epidemiology and Infection·J ÁlvarezL de Juan
Apr 13, 2011·Veterinary Microbiology·Heidi MikkelsenGregers Jungersen
Feb 22, 2012·Cellular Microbiology·Dmitriy IgnatovAlexander Apt
Sep 26, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Tomotada IwamotoYasuhiko Suzuki
Nov 22, 2014·Frontiers in Immunology·Kévin Rue-AlbrechtDavid E MacHugh
Feb 20, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E CastellanosJ De Buck
Feb 23, 2020·Nature Reviews. Microbiology·Matt D JohansenLaurent Kremer
Mar 5, 2021·Frontiers in Veterinary Science·Rachel MizziKarren M Plain
Apr 4, 2021·International Journal of Molecular Sciences·Min-Kyoung Shin, Sung Jae Shin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Laura Rindi, Carlo Garzelli
Clinical & Developmental Immunology
Samantha L Sampson
© 2021 Meta ULC. All rights reserved