Genomic copy number analysis of Chernobyl papillary thyroid carcinoma in the Ukrainian-American Cohort

Carcinogenesis
M SelmansbergerK Unger

Abstract

One of the major consequences of the 1986 Chernobyl reactor accident was a dramatic increase in papillary thyroid carcinoma (PTC) incidence, predominantly in patients exposed to the radioiodine fallout at young age. The present study is the first on genomic copy number alterations (CNAs) of PTCs of the Ukrainian-American cohort (UkrAm) generated by array comparative genomic hybridization (aCGH). Unsupervised hierarchical clustering of CNA profiles revealed a significant enrichment of a subgroup of patients with female gender, long latency (>17 years) and negative lymph node status. Further, we identified single CNAs that were significantly associated with latency, gender, radiation dose and BRAF V600E mutation status. Multivariate analysis revealed no interactions but additive effects of parameters gender, latency and dose on CNAs. The previously identified radiation-associated gain of the chromosomal bands 7q11.22-11.23 was present in 29% of cases. Moreover, comparison of our radiation-associated PTC data set with the TCGA data set on sporadic PTCs revealed altered copy numbers of the tumor driver genes NF2 and CHEK2. Further, we integrated the CNA data with transcriptomic data that were available on a subset of the herein ana...Continue Reading

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Citations

Mar 28, 2017·International Journal of Radiation Biology·Werner RühmJan Christian Kaiser
Apr 27, 2017·International Journal of Molecular Sciences·Elisabetta AlbiFrancesco Curcio
Aug 31, 2018·Radiation Protection Dosimetry·Geraldine Thomas
Sep 21, 2017·European Journal of Epidemiology·Maureen Hatch, Elisabeth Cardis

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