Abstract
Abnormalities of the genomic region of chromosome 19q13.2-13.4 are a common occurrence in brain malignancies and contain a possible tumor suppressor gene involved in gliomas. Since abnormalities of DNA repair are associated with malignancy, we assessed DNA status of the nucleotide excision repair genes located in this area, viz. ERCC1 and ERCC2. Radiodensitometry was used to assess gene copy number in samples obtained from brain tumor specimens from 24 patients. Nine tumors were of lower grade histology (3 pilocytic astrocytomas, 2 gangliogliomas, 4 astrocytomas); 15 tumors were pathologically higher grade (4 anaplastic astrocytomas, 11 glioblastomas). Tumor samples were obtained prior to radiation or chemotherapy. Abnormalities of gene copy number of ERCC1 and ERCC2 were observed in 11/24 specimens (46%). Whereas increased and decreased copy numbers were observed for ERCC1, only decreases in copy number of ERCC2 were seen. Three tumors (all lower grade) showed concurrent allelic loss of ERCC1 and ERCC2. Abnormalities of copy number for these genes were not associated with response to subsequent therapy nor survival. However, allelic loss of ERCC2 was associated with younger age at diagnosis when compared to those specimens whi...Continue Reading
References
Oct 7, 1992·Journal of the National Cancer Institute·M DabholkarE Reed
Jul 1, 1992·British Journal of Cancer·A M Taylor
Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·W L FlejterR A Schultz
Jan 1, 1992·Genomics·D E BarnesH W Mohrenweiser
Mar 28, 1986·Cell·M van DuinD Bootsma
Nov 15, 1988·Cancer·C Daumas-DuportP Kelly
Aug 2, 1984·Nature·A WesterveldD Bootsma
Jan 1, 1994·Journal of Neuro-oncology·L G FeunH J Landy
Sep 15, 1994·International Journal of Cancer. Journal International Du Cancer·T AbeM Kuwano
Nov 4, 1994·Science·J Marx
Aug 1, 1994·The Journal of Clinical Investigation·M DabholkarE Reed
Aug 11, 1994·Nucleic Acids Research·F Larminat, V A Bohr
Sep 21, 1994·Journal of the National Cancer Institute·H T LynchP Peltomäki
Feb 1, 1994·Trends in Biochemical Sciences·K Tanaka, R D Wood
Jun 1, 1994·International Journal of Cancer. Journal International Du Cancer·A von DeimlingO D Wiestler
Oct 1, 1993·Carcinogenesis·K B LeeE Reed
Dec 17, 1993·Cell·R ParsonsP Modrich
Citations
Nov 29, 1996·Cancer Letters·J C States, E Reed
Mar 30, 2000·Cancer Letters·J J YuE Reed
Dec 23, 1998·Cancer Treatment Reviews·E Reed
Mar 26, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Roberta McKean-CowdinMargaret Wrensch
Oct 23, 2013·BMC Cancer·David Hersi SmithKirsten Vang Nielsen
Dec 12, 2013·Gene·Irene Rodriguez-HernandezRogelio Gonzalez-Sarmiento
Aug 3, 2010·Journal français d'ophtalmologie·K El Ouazzani ChahdiR Daoudi
Jun 28, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Li-Ming HuangXue-De Lin
Jul 1, 1997·Gynecologic Oncology·A BicherB Liang
Sep 28, 2016·International Journal of Cancer. Journal International Du Cancer·Gustav van NiekerkAnna-Mart Engelbrecht
Oct 7, 2003·American Journal of Clinical Oncology·David MurrayM Joan Allalunis-Turner
Apr 23, 2016·Journal of Nursing Measurement·Jeanine Seguin Santelli
May 20, 1998·Neurosurgery·Z P ChenL C Panasci
Jun 21, 2018·Journal of Neuro-oncology·Lei TangLi Yang
Aug 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Florence KoeppelAnnette K Larsen