PMID: 9530627Apr 8, 1998Paper

Genomic DNA sequence of Rhesus (M. mulatta) cystic fibrosis (CFTR) gene

Mammalian Genome : Official Journal of the International Mammalian Genome Society
Jeffrey J WineM Dean

Abstract

Cystic fibrosis is a common human genetic disease caused by mutations in CFTR, a gene that codes for a chloride channel that is regulated by phosphorylation and cytosolic nucleotides. As part of a program to discover natural animal models for human genetic diseases, we have determined the genomic sequence of CFTR in the Rhesus monkey, Macaca mulatta. The coding region of rhesus CFTR is 98.3% identical to human CFTR at the nucleotide level and 98.2% identical and 99.7% similar at the amino acid level. Partial sequences of flanking introns (5582 base pair positions analyzed) revealed 91.1% identity with human introns. Relative to rhesus intronic sequence, the human sequences had 27 insertions and 22 deletions. Primer sequences for amplification of rhesus genomic CFTR sequences are provided. The accession number is AF013753 (all 27 exons and some flanking intronic sequence).

References

Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·L L ClarkeR C Boucher
Mar 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·S J TebbuttA Harris
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Citations

Oct 28, 2005·European Journal of Human Genetics : EJHG·Fiorenza PompeiPier Franco Pignatti
Sep 11, 2008·Annals of Human Genetics·N SharmaR Prasad
May 20, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Christopher S RogersMichael J Welsh
Sep 26, 2000·Molecular Genetics and Metabolism·J M ChenC Ferec
Nov 25, 2020·The American Journal of Pathology·Alexandra McCarronMartin Donnelley
Feb 7, 2001·Pediatrics·J J WineR B Moss

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