Genomic environment influences the dynamics of the tirant LTR retrotransposon in Drosophila

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Marie FabletCristina Vieira

Abstract

Combining genome sequence analysis and functional analysis, we show that some full-length copies of tirant are present in heterochromatic regions in Drosophila simulans and that when tested in vitro, these copies have a functional promoter. However, when inserted in heterochromatic regions, tirant copies are inactive in vivo, and only transcription of euchromatic copies can be detected. Thus, our data indicate that the localization of the element is a hallmark of its activity in vivo and raise the question of genomic invasions by transposable elements and the importance of their genomic integration sites.

References

Jan 1, 1989·Annual Review of Genetics·B Charlesworth, C H Langley
Jan 1, 1986·Journal of Molecular Evolution·S B Daniels, L D Strausbaugh
Feb 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·A KimA Bucheton
Jul 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·L V MatyuninaJ F McDonald
Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Sep 16, 1999·Molecular Biology and Evolution·C VieiraC Biémont
Feb 7, 2001·Molecular Biology and Evolution·I BusseauA Bucheton
Jan 23, 2003·Genome Biology·Joshua S KaminkerSusan E Celniker
Feb 5, 2003·Genome Research·Xiaoping SunGary H Karpen
Mar 20, 2003·Evolution; International Journal of Organic Evolution·Christian BiémontCristina Vieira
May 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Vladimir V Kapitonov, Jerzy Jurka
Jul 19, 2003·Genome Research·Emmanuelle LeratChristian Biémont
Jan 30, 2004·Molecular and Cellular Biology·Ralf StrohnerGernot Längst
Dec 3, 2004·Molecular Biology and Evolution·Nathalie MugnierCristina Vieira
Aug 12, 2005·Cytogenetic and Genome Research·C Biémont, C Vieira
Jul 6, 2006·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Anja EbertGunter Reuter
Oct 7, 2006·Nature·Christian Biémont, Cristina Vieira
Jun 16, 2007·Science·Roger A HoskinsSusan E Celniker
Feb 23, 2008·Current Opinion in Cell Biology·Alexandra M Pietersen, Maarten van Lohuizen

❮ Previous
Next ❯

Citations

Jan 28, 2010·Gene·Rita RebolloCristina Vieira
Aug 5, 2014·Mobile Genetic Elements·Cassiane Martins BarbosaFernanda Antunes Alves-Costa
Nov 29, 2020·Molecular Biology and Evolution·Florian SchwarzRobert Kofler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.