c-Fos-MMP-9 pathway in central amygdala mediates approach motivation but not reward consumption

BioRxiv : the Preprint Server for Biology
T. LebitkoEwelina Knapska

Abstract

Although impairments of motivational and consummatory aspects of reward behavior are core symptoms of several psychiatric disorders, the underlying neural and molecular mechanisms remain poorly understood. Here we report that blocking either c-Fos or matrix metalloproteinase 9 in the central amygdala disrupts approach motivation and appetitive discrimination learning, but not reward consumption. Further, we show that manipulation of c-Fos-MMP-9 pathway does not affect aversive motivation and learning. These findings reveal molecular mechanism of motivational anhedonia.

Related Concepts

Pathogenic Aspects
Pathogenesis
Population Biology
Genome
Genes
CRISPR-Cas Systems
Pathogenic Organism
Elizabethkingia miricola
Identification (Psychology)
Environment

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