Genomic Epidemiology of Global Carbapenemase-Producing Enterobacter spp., 2008-2014

Emerging Infectious Diseases
Gisele PeiranoJohann D D Pitout

Abstract

We performed whole-genome sequencing on 170 clinical carbapenemase-producing Enterobacter spp. isolates collected globally during 2008-2014. The most common carbapenemase was VIM, followed by New Delhi metallo-β-lactamase (NDM), Klebsiella pneumoniae carbapenemase, oxacillin 48, and IMP. The isolates were of predominantly 2 species (E. xiangfangensis and E. hormaechei subsp. steigerwaltii) and 4 global clones (sequence type [ST] 114, ST93, ST90, and ST78) with different clades within ST114 and ST90. Particular genetic structures surrounding carbapenemase genes were circulating locally in various institutions within the same or between different STs in Greece, Guatemala, Italy, Spain, Serbia, and Vietnam. We found a common NDM genetic structure (NDM-GE-U.S.), previously described on pNDM-U.S. from Klebsiella pneumoniae ATCC BAA-214, in 14 different clones obtained from 6 countries spanning 4 continents. Our study highlights the importance of surveillance programs using whole-genome sequencing in providing insight into the molecular epidemiology of carbapenemase-producing Enterobacter spp.

References

Sep 6, 2003·Applied and Environmental Microbiology·Harald Hoffmann, Andreas Roggenkamp
Jun 16, 2011·Nucleic Acids Research·You ZhouDavid S Wishart
Oct 18, 2011·Emerging Infectious Diseases·Patrice NordmannLaurent Poirel
Jul 12, 2012·The Journal of Antimicrobial Chemotherapy·Ea ZankariMette Voldby Larsen
Feb 15, 2013·Molecular Biology and Evolution·Lu ChengJukka Corander
Oct 8, 2013·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Sergey NurkPavel A Pevzner
Apr 30, 2014·Antimicrobial Agents and Chemotherapy·Alessandra CarattoliHenrik Hasman
Sep 14, 2014·The Journal of Antimicrobial Chemotherapy·R IzdebskiUNKNOWN MOSAR WP2, WP3 and WP5 Study Groups
Oct 24, 2014·Emerging Infectious Diseases·Gisele PeiranoJohann D D Pitout
Nov 22, 2014·Nucleic Acids Research·Nicholas J CroucherSimon R Harris
Jul 15, 2015·Antimicrobial Agents and Chemotherapy·Johann D D PitoutLaurent Poirel
Aug 27, 2015·International Journal of Antimicrobial Agents·Javier FernándezM Rosario Rodicio
Sep 25, 2015·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Tsilia LazarovitchDror Marchaim
Nov 12, 2015·Frontiers in Microbiology·Thomas GuillardChristophe de Champs On Behalf Of CarbaFrEst Group
Feb 7, 2016·The Journal of Antimicrobial Chemotherapy·Marisa HaenniJean-Yves Madec
Apr 27, 2016·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Xiao-Li CaoHan Shen
May 14, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Branka BedenićGernot Zarfel
Sep 30, 2016·Frontiers in Microbiology·Daniela Jones-DiasManuela Caniça
Jul 26, 2017·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·D De BelderS A Gomez
Nov 28, 2017·Microbial Genomics·Sergio Arredondo-AlonsoAnita C Schürch

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Citations

Feb 1, 2019·Clinical Microbiology Reviews·Wenjing WuZhiyong Zong
Jul 19, 2019·Clinical Microbiology Reviews·Anne Davin-RegliJean-Marie Pagès
Aug 30, 2019·Journal of Clinical Microbiology·Gisele PeiranoJohann D D Pitout
Nov 15, 2019·Clinical Microbiology Reviews·Johann D D PitoutYasufumi Matsumura
Feb 28, 2020·Clinical Microbiology Reviews·Karen Bush, Patricia A Bradford
May 15, 2020·Clinical Microbiology Reviews·David M P De OliveiraMark J Walker
Feb 16, 2019·Frontiers in Microbiology·Medini K AnnavajhalaAnne-Catrin Uhlemann
Oct 28, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Snežana BrkićIvana Ćirković
Aug 20, 2020·Expert Review of Anti-infective Therapy·Juan Carlos García-BetancurMaría Virginia Villegas
Aug 15, 2019·Implementation Science : IS·Nina Van GoethemAnnie Robert
Aug 12, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·William StokesDaniel Gregson
Jan 11, 2020·Frontiers in Microbiology·Fernando BaqueroVal F Lanza
Oct 23, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Miriam MateosRafael Cantón
Dec 15, 2020·Journal of Global Antimicrobial Resistance·Ghada El-Saeed Mashaly, Mervat El-Sayed Mashaly
Jan 13, 2021·Trends in Microbiology·Zhiyong ZongAlan McNally
Jan 26, 2021·International Journal of Antimicrobial Agents·Rémy A BonninThierry Naas
Oct 31, 2020·Scientific Reports·Philipp KohlerUNKNOWN Toronto Invasive Bacterial Diseases Network (TIBDN)
Nov 18, 2020·International Journal of Molecular Sciences·Corneliu Ovidiu VrancianuMariana Carmen Chifiriuc
Nov 22, 2020·Emerging Infectious Diseases·Gisele PeiranoJohann D D Pitout
Nov 27, 2018·International Journal of Antimicrobial Agents·Sika DossimLaurent Dortet
May 7, 2021·Journal of Global Antimicrobial Resistance·Edgar I Campos-MaduenoAndrea Endimiani
May 19, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Jana MakhloufSima Tokajian
Jul 15, 2021·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·William StokesJohann D D Pitout
Jul 16, 2021·Microbiology Resource Announcements·Soon Keong WeeEric Peng Huat Yap
Jun 29, 2021·Antimicrobial Agents and Chemotherapy·Edgar I Campos-MaduenoAndrea Endimiani

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Datasets Mentioned

BETA
PRJNA259658
PRJNA398291

Software Mentioned

PHAST
BLAST
PlasmidFinder
ResFinder
SPAdes
RAxML
Bayesian Analysis of Population Structure

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