Genomic epidemiology of severe community-onset Acinetobacter baumannii infection

Microbial Genomics
Ella M MeumannDerek S Sarovich

Abstract

Acinetobacter baumannii causes severe, fulminant, community-acquired pneumonia (CAP) in tropical and subtropical regions. We compared the population structure, virulence and antimicrobial resistance determinants of northern Australian community-onset A. baumannii strains with local and global strains. We performed whole-genome sequencing on 55 clinical and five throat colonization A. baumannii isolates collected in northern Australia between 1994 and 2016. Clinical isolates included CAP (n=41), healthcare-associated pneumonia (n=7) and nosocomial bloodstream (n=7) isolates. We also included 93 publicly available international A. baumannii genome sequences in the analyses. Patients with A. baumannii CAP were almost all critically unwell; 82 % required intensive care unit admission and 18 % died during their inpatient stay. Whole-genome phylogenetic analysis demonstrated that community-onset strains were not phylogenetically distinct from nosocomial strains. Some non-multidrug-resistant local strains were closely related to multidrug-resistant strains from geographically distant locations. Pasteur sequence type (ST)10 was the dominant ST and accounted for 31/60 (52 %) northern Australian strains; the remainder belonged to a diver...Continue Reading

References

Jan 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·N M AnsteyK M Withnall
May 1, 1995·Antimicrobial Agents and Chemotherapy·J VilaT Jimenez de Anta
Jun 1, 1997·The Journal of Antimicrobial Chemotherapy·J VilaT Jimenez de Anta
May 8, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P Huovinen
May 3, 2003·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Cosmina ZeanaPhyllis Della-Latta
Jun 29, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Clinton K MurrayMyron J Tong
Feb 9, 2008·Emerging Infectious Diseases·James W T ElstonCraig S Boutlis
Feb 19, 2008·Journal of Bacteriology·Chen NiuPhilip N Rather
Jul 10, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter J SebenyKyle Petersen
Jul 16, 2008·Clinical Microbiology Reviews·Anton Y PelegDavid L Paterson
Apr 7, 2010·PLoS Pathogens·Laura CamarenaMichael Snyder
Jul 21, 2010·Infection and Immunity·Thomas A RussoAnthony A Campagnari
Mar 26, 2013·PloS One·Daniel N FarrugiaIan T Paulsen
May 16, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Matthieu EveillardMarie-Laure Joly-Guillou
May 22, 2013·Antimicrobial Agents and Chemotherapy·Greg HarrisWangxue Chen
Mar 20, 2014·Bioinformatics·Torsten Seemann
Apr 3, 2014·Carbohydrate Research·Evgeny VinogradovWangxue Chen
Nov 6, 2014·Molecular Biology and Evolution·Lam-Tung NguyenBui Quang Minh
Nov 26, 2014·Genome Medicine·Michael InouyeKathryn E Holt
Jan 27, 2015·Applied and Environmental Microbiology·Rayane RafeiMarie Kempf
Feb 13, 2015·PLoS Computational Biology·Xavier Didelot, Daniel J Wilson
Apr 1, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Crystal L JonesEmil Lesho
Apr 9, 2015·Expert Review of Anti-infective Therapy·Carina DexterAnton Y Peleg
Jun 21, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Hélène PailhorièsMatthieu Eveillard
Jul 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Brent S WeberMario F Feldman
Nov 19, 2015·Nucleic Acids Research·Lihong ChenQi Jin

❮ Previous
Next ❯

Datasets Mentioned

BETA
PRJNA478282

Software Mentioned

Interactive Tree of Life
TREE
MGAP
ClonalFrameML
Abricate
SPANDx
IQ
PAUP
BEAST

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.

Biofilms

Biofilms are adherent bacterial communities embedded in a polymer matrix and can cause persistent human infections that are highly resistant to antibiotics. Discover the latest research on Biofilms here.

Acinetobacter Infections

Acinetobacter infections have become common in hospitalized patients, especially in the intensive care unit setting and are difficult to treat due to their propensity to develop antimicrobial drug resistance. Discover the latest research on Acinetobacter Infections here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.