Apr 2, 2020

Feminisation of complex traits in Drosophila melanogaster via female-limited X chromosome evolution

BioRxiv : the Preprint Server for Biology
Katrine Koch Lund-HansenE. H. Morrow

Abstract

A handful of studies have investigated sexually antagonistic constraints on obtaining sex-specific fitness optima, though exclusively through male-genome-limited evolution experiments. In this paper, we established a female-limited X chromosome evolution experiment, where we used an X chromosome balancer to enforce the inheritance of the X chromosome through the matriline, thus removing exposure to male selective constraints. This approach eliminates the effects of sexually antagonistic selection on the X chromosome, permitting evolution towards a single sex-specific optimum. After multiple generations of selection, we found strong evidence that body size and development time had moved towards a female-specific optimum, whereas reproductive fitness and locomotion activity remained unchanged. The changes in body size and development time are consistent with previous results, and suggest that the X chromosome is enriched for sexually antagonistic genetic variation controlling these traits. The lack of change in reproductive fitness and locomotion activity could be due to a number of mutually non-exclusive explanations, including a lack of sexually antagonistic variance on the X chromosome or confounding effects of the use of the ...Continue Reading

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Mentioned in this Paper

Patterns
Genome
Genes
Public Health Surveillance
Radicals (chemistry)
Malaria
Malaria Vaccines
Genomics
Standing Position
Resistance Process

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