Genomic Epidemiology of USA300 Methicillin-Resistant Staphylococcus aureus in an Urban Community

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Kyle J PopovichRobert A Weinstein

Abstract

In a community, it is unknown what factors account for transmission of methicillin-resistant Staphylococcus aureus (MRSA). We integrated whole genome sequencing (WGS) and epidemiologic data to identify factors associated with MRSA transmission networks in an urban community. WGS was performed on colonizing USA300 MRSA isolates from 74 individuals within 72 hours of admission to a public hospital in Chicago, IL. Single nucleotide variants (SNVs) were used to reconstruct the phylogeny of sequenced isolates, and epidemiologic data was overlaid to identify factors associated with transmission networks. The maximum within-patient SNV difference for an individual with multisite colonization was 41 SNVs, with no systematic divergence among body sites. We observed a minimum of 7 SNVs and maximum of 153 SNVs between isolates from different individuals. We identified 4 pairs of individuals whose isolates were within 40 SNVs of each other. Putting our isolates in the context of previously sequenced USA300 isolates from other communities, we identified a 13-member group and two 4-member groups that represent samples from putative local transmission networks. Individuals in these groups were more likely to be African American, to be human i...Continue Reading

References

Mar 5, 1998·JAMA : the Journal of the American Medical Association·B C HeroldR S Daum
Jan 18, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Edwin D CharleboisFrançoise Perdreau-Remington
Aug 13, 2003·Bioinformatics·Fredrik Ronquist, John P Huelsenbeck
Jun 19, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Edwin D CharleboisHenry F Chambers
Apr 9, 2005·The New England Journal of Medicine·Scott K FridkinUNKNOWN Active Bacterial Core Surveillance Program of the Emerging Infections Program Network
Apr 22, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nolan E LeePaul A Simon
Feb 9, 2006·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·David M HartleyEli N Perencevich
Aug 18, 2006·The New England Journal of Medicine·Gregory J MoranUNKNOWN EMERGEncy ID Net Study Group
Aug 19, 2007·The Journal of Infectious Diseases·Franklin D LowyElaine L Larson
Jul 14, 2009·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Timothy F LandersKurt B Stevenson
Mar 3, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kyle J PopovichBala Hota
Nov 3, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cynthia L MareeLoren G Miller
Feb 25, 2011·The New England Journal of Medicine·Jennifer L GardyPatrick Tang
Feb 23, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kyle J PopovichBala Hota
Jun 15, 2012·The New England Journal of Medicine·Claudio U KöserSharon J Peacock
Jan 18, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kyle J PopovichRobert A Weinstein
May 10, 2013·PloS One·Tanya GolubchikRory Bowden
Sep 18, 2013·JAMA Internal Medicine·Raymund DantesUNKNOWN Emerging Infections Program–Active Bacterial Core Surveillance MRSA Surveillance Investigators
Oct 18, 2013·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Dec 18, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·James R PriceMartin J Llewelyn
Apr 23, 2014·Proceedings of the National Academy of Sciences of the United States of America·Anne-Catrin UhlemannFranklin D Lowy
Aug 12, 2014·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Kyle J PopovichRobert A Weinstein
Oct 1, 2008·American Sociological Review·Barrett A LeeDavid O'Sullivan
Sep 16, 2015·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Yoona RheeKyle J Popovich

❮ Previous
Next ❯

Citations

Apr 19, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Eugene V MillarKimberly A Bishop-Lilly
May 4, 2018·Molecular Biology and Evolution·Seth N RedmondDaniel E Neafsey
Mar 11, 2017·Current Infectious Disease Reports·Kyle J Popovich, Evan S Snitkin
Apr 11, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lona ModyLillian Min
Dec 3, 2020·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Maíris Alarcão Duarte de Oliveira SilvestreCarlos Magno Castelo Branco Fortaleza
Jan 5, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kyle J PopovichRobert A Weinstein
Jun 3, 2021·Microorganisms·Rajan P Adhikari
Jun 24, 2021·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Maria A ArgudínMarie Hallin

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR & Staphylococcus

CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.

Related Papers

Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
John A JerniganWilliam R Jarvis
European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
J H WagenvoortB I Davies
© 2021 Meta ULC. All rights reserved