Genomic Evidence for Adaptive Inversion Clines in Drosophila melanogaster

Molecular Biology and Evolution
Martin KapunT Flatt

Abstract

Clines in chromosomal inversion polymorphisms-presumably driven by climatic gradients-are common but there is surprisingly little evidence for selection acting on them. Here we address this long-standing issue in Drosophila melanogaster by using diagnostic single nucleotide polymorphism (SNP) markers to estimate inversion frequencies from 28 whole-genome Pool-seq samples collected from 10 populations along the North American east coast. Inversions In(3L)P, In(3R)Mo, and In(3R)Payne showed clear latitudinal clines, and for In(2L)t, In(2R)NS, and In(3R)Payne the steepness of the clinal slopes changed between summer and fall. Consistent with an effect of seasonality on inversion frequencies, we detected small but stable seasonal fluctuations of In(2R)NS and In(3R)Payne in a temperate Pennsylvanian population over 4 years. In support of spatially varying selection, we observed that the cline in In(3R)Payne has remained stable for >40 years and that the frequencies of In(2L)t and In(3R)Payne are strongly correlated with climatic factors that vary latitudinally, independent of population structure. To test whether these patterns are adaptive, we compared the amount of genetic differentiation of inversions versus neutral SNPs and foun...Continue Reading

References

Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·W W AndersonD E Jeffery
Apr 1, 1988·Trends in Genetics : TIG·J R David, P Capy
Mar 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·T Dobzhansky, F J Ayala
Mar 31, 2001·Genetical Research·P AndolfattoA Navarro
Jun 14, 2001·Trends in Ecology & Evolution·L H. Rieseberg
Oct 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·M A NoorJ Reiland
Apr 27, 2002·Genetical Research·Sylvie AulardFrançoise Lemeunier
Jun 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Stephen W SchaefferWyatt W Anderson
Jan 18, 2005·Nature Genetics·Hreinn StefanssonKari Stefansson
Oct 6, 2005·Genetics·Mark Kirkpatrick, Nick Barton
Aug 1, 1921·Proceedings of the National Academy of Sciences of the United States of America·A H Sturtevant
May 17, 2006·Trends in Ecology & Evolution·Ary A HoffmannAndrew R Weeks
Jun 10, 2006·Science·William E Bradshaw, Christina M Holzapfel
Feb 27, 2008·Evolution; International Journal of Organic Evolution·Paul S Schmidt, Annalise B Paaby
May 22, 2008·Genetics·Thomas L TurnerDavid J Begun
Sep 4, 2008·Evolution; International Journal of Organic Evolution·Stephen W Schaeffer
Oct 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Paul S SchmidtWalter F Eanes
Feb 3, 2009·Fly·Annalise B Paaby, Paul S Schmidt
Jul 22, 2009·Biochimica Et Biophysica Acta·Thomas Flatt, Paul S Schmidt
Dec 1, 2008·Annual Review of Ecology, Evolution, and Systematics·Ary A Hoffmann, Loren H Rieseberg
Sep 15, 2010·Molecular Biology and Evolution·Diego AyalaFrédéric Simard
Oct 12, 2010·PLoS Biology·Mark Kirkpatrick
Aug 16, 2011·Nature·Mathieu JoronRichard H ffrench-Constant
Dec 28, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Rafael F GuerreroMark Kirkpatrick
Feb 10, 2012·Nature·Trudy F C MackayRichard A Gibbs

❮ Previous
Next ❯

Citations

Feb 22, 2017·Scientific Reports·Rodrigo CogniWalter F Eanes
Jan 11, 2017·Evolution; International Journal of Organic Evolution·Diego AyalaDidier Fontenille
Feb 24, 2018·Molecular Ecology·Ann-Marie WaldvogelMarkus Pfenninger
May 8, 2018·Proceedings of the National Academy of Sciences of the United States of America·Iskander SaidRussell Corbett-Detig
Dec 22, 2017·Methods in Ecology and Evolution·R Axel W WibergMichael G Ritchie
Aug 10, 2017·Molecular Ecology·Rafael F Guerrero, Matthew W Hahn
Jun 16, 2018·Journal of Evolutionary Biology·Esra DurmazThomas Flatt
Apr 13, 2018·Evolution; International Journal of Organic Evolution·Quentin Rougemont, Louis Bernatchez
Aug 21, 2018·BMC Biology·Thomas Flatt, Linda Partridge
Nov 13, 2018·Evolution; International Journal of Organic Evolution·Clementine LasneTim Connallon
Jan 13, 2018·Proceedings. Biological Sciences·Emily L BehrmanPaul S Schmidt
May 22, 2019·Evolution; International Journal of Organic Evolution·Esra DurmazThomas Flatt
Sep 19, 2019·Proceedings of the National Academy of Sciences of the United States of America·Seth M RudmanPaul Schmidt
Aug 9, 2019·G3 : Genes - Genomes - Genetics·R Rebecca LoveNora J Besansky
Nov 16, 2019·Molecular Biology and Evolution·Quentin D SprengelmeyerJohn E Pool
Apr 4, 2020·Journal of Evolutionary Biology·Franziska GünterKlaus Fischer
May 22, 2020·Genome Biology and Evolution·Jakob McBroomeRussell Corbett-Detig
Oct 6, 2020·Evolution Letters·Aryn P WilderNina Overgaard Therkildsen
Jul 11, 2018·Proceedings of the National Academy of Sciences of the United States of America·Changde ChengNora J Besansky
Feb 23, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Judit Salces-OrtizJosefa González

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.