PMID: 9420479Jan 1, 1997Paper

Genomic evolution of the distal Mhc class I region on mouse Chr 17

Hereditas
M YoshinoK Fischer Lindahl

Abstract

A 5-Mb YAC contig, partly supplemented with BAC contigs, was created from the distal Mhc class I region on mouse Chr 17. The gene order of Znf173-Tctex5-Mog-D17Tu42-D17Leh 89 is conserved between mouse and human but not the physical distance, supporting the independent expansion of Mhc class I genes in the so-called accordion model of Mhc evolution. The distal H2-M region includes the breakpoint of conserved synteny between mouse and human as well as the In(17)4 t-inversion. The H2-M region is rich in L1 repeats, implying that the insertion of L1 repeats may be associated with the evolutionary flexibility to break a chromosome.

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Citations

May 13, 1999·Immunological Reviews·C AmadouK F Lindahl
Dec 2, 2004·Nature Reviews. Genetics·Roger HortonStephan Beck
Sep 25, 2003·Human Molecular Genetics·Claire AmadouKirsten Fischer Lindahl
Jan 31, 2009·Antioxidants & Redox Signaling·Youngkyun KimKwangseog Ahn
Mar 21, 1998·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M YoshinoK F Lindahl

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