Genomic expression analysis of rat chromosome 4 for skeletal traits at femoral neck.

Physiological Genomics
Imranul AlamC H Turner

Abstract

Hip fracture is the most devastating osteoporotic fracture type with significant morbidity and mortality. Several studies in humans and animal models identified chromosomal regions linked to hip size and bone mass. Previously, we identified that the region of 4q21-q41 on rat chromosome (Chr) 4 harbors multiple femoral neck quantitative trait loci (QTLs) in inbred Fischer 344 (F344) and Lewis (LEW) rats. The purpose of this study is to identify the candidate genes for femoral neck structure and density by correlating gene expression in the proximal femur with the femoral neck phenotypes linked to the QTLs on Chr 4. RNA was extracted from proximal femora of 4-wk-old rats from F344 and LEW strains, and two other strains, Copenhagen 2331 and Dark Agouti, were used as a negative control. Microarray analysis was performed using Affymetrix Rat Genome 230 2.0 arrays. A total of 99 genes in the 4q21-q41 region were differentially expressed (P < 0.05) among all strains of rats with a false discovery rate <10%. These 99 genes were then ranked based on the strength of correlation between femoral neck phenotypes measured in F2 animals, homozygous for a particular strain's allele at the Chr 4 QTL and the expression level of the gene in that ...Continue Reading

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Citations

Oct 21, 2009·Functional & Integrative Genomics·Imranul AlamCharles H Turner
Apr 2, 2010·Endocrine Reviews·Xiang-Hong XuHong-Wen Deng
Mar 20, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Imranul AlamTatiana Foroud
Mar 5, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Imranul AlamCharles H Turner
Jul 15, 2015·BoneKEy Reports·Douglas J Adams, Cheryl L Ackert-Bicknell
Aug 23, 2019·Bone·Robert BrommageJeff Liu

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