Genomic expression patterns in menstrual-related migraine in adolescents

Headache
Andrew D HersheyScott W Powers

Abstract

Exacerbation of migraine with menses is common in adolescent girls and women with migraine, occurring in up to 60% of females with migraine. These migraines are oftentimes longer and more disabling and may be related to estrogen levels and hormonal fluctuations. This study identifies the unique genomic expression pattern of menstrual-related migraine (MRM) in comparison to migraine occurring outside the menstrual period and headache-free controls. Whole blood samples were obtained from female subjects having an acute migraine during their menstrual period (MRM) or outside of their menstrual period (non-MRM) and controls (C)--females having a menstrual period without any history of headache. The messenger RNA was isolated from these samples, and genomic profile was assessed. Affymetrix Human Exon ST 1.0 (Affymetrix, Santa Clara, CA, USA) arrays were used to examine the genomic expression pattern differences between these 3 groups. Blood genomic expression patterns were obtained on 56 subjects (MRM = 18, non-MRM = 18, and controls = 20). Unique genomic expression patterns were observed for both MRM and non-MRM. For MRM, 77 genes were identified that were unique to MRM, while 61 genes were commonly expressed for MRM and non-MRM, a...Continue Reading

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Citations

Jul 21, 2012·Current Pain and Headache Reports·Andrew D Hershey
Aug 31, 2012·Current Pain and Headache Reports·Cristina TassorelliRossella E Nappi
Apr 4, 2013·Current Opinion in Neurology·Amy A Gelfand
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Jan 7, 2017·Cephalalgia : an International Journal of Headache·Zachary F GerringDale R Nyholt
Mar 23, 2017·Epilepsy Research·Markus von DeimlingHiltrud Muhle
Feb 11, 2016·Cephalalgia : an International Journal of Headache·Zachary GerringDale R Nyholt
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Dec 1, 2018·The Journal of Headache and Pain·Zoë DelaruelleUNKNOWN European Headache Federation School of Advanced Studies (EHF-SAS)

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