Genomic features and evolutionary constraints in Saffold-like cardioviruses

The Journal of General Virology
Jan Felix DrexlerAlexander Lukashev

Abstract

This study identified the complete genomic sequence of four type 2 and type 3 human Saffold-like cardioviruses (SLCVs) isolated in Germany and Brazil. The secondary structures of the SLCV internal ribosome entry sites (IRESs) were deduced based on RNA base-pairing conservation and co-variation, using an established Theiler's murine encephalomyelitis virus (TMEV) IRES structure as a reference. The SLCV IRES was highly similar to that of TMEV, but motifs critical in TMEV for binding of the polypyrimidine tract-binding protein (PTB) were disrupted. In TMEV, corresponding alterations have been associated with reduced neurovirulence in mice. In the non-structural genome region, there was evidence of multiple intertypic recombination events between different SLCV types. Between viruses of the same type, recombination also occurred in the capsid-encoding genome region. There were apparently no recombination events between mouse TMEV and human SLCV. In another genus of the family Picornaviridae, Enterovirus, natural recombination occurs strictly within species and can serve as an additional criterion for delimiting species. Accordingly, the results of this study suggest that SLCV and TMEV may represent distinct species within the genus...Continue Reading

References

Aug 7, 1989·The Medical Journal of Australia·B Hocking
May 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J W Drake
Jun 11, 1999·Journal of Virology·P Simmonds, D B Smith
Jun 21, 2001·Proceedings of the National Academy of Sciences of the United States of America·T V PestovaC U Hellen
May 7, 2002·Journal of Medical Virology·Chun-Yi LuLi-Min Huang
Jun 26, 2003·Nucleic Acids Research·Michael Zuker
Aug 13, 2003·Bioinformatics·Fredrik Ronquist, John P Huelsenbeck
Sep 13, 2003·Journal of Virology·Alexander N LukashevJorma Ilonen
Dec 4, 2004·Reviews in Medical Virology·Alexander N Lukashev
Dec 15, 2005·Journal of Virology·Peter Simmonds, Jon Welch
Sep 1, 2006·Journal of Clinical Microbiology·Elisabet WitsøKjersti S Rønningen
Feb 22, 2007·Journal of Medical Virology·Sisko TauriainenHeikki Hyöty
May 10, 2007·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Nov 13, 2007·BMC Evolutionary Biology·Alexei J Drummond, Andrew Rambaut
Feb 7, 2008·Emerging Infectious Diseases·Vsevolod A VladimirtsevLev G Goldfarb
Apr 29, 2008·Emerging Infectious Diseases·Yacine Abed, Guy Boivin
Jun 19, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Katja C WolthersDasja Pajkrt
Sep 2, 2008·Emerging Infectious Diseases·Jan Felix DrexlerChristian Drosten
Sep 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Charles Y ChiuJoseph L DeRisi
Sep 26, 2008·Journal of Virology·Zhiguo LiangHoward L Lipton
Jan 13, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·E C McWilliam LeitchP Simmonds

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Citations

Nov 10, 2010·Nature Reviews. Microbiology·Vadim I Agol, Anatoly P Gmyl
May 6, 2011·Journal of Virology·Shannon HertzlerHoward L Lipton
Jul 30, 2010·Journal of Virology·Chloe L McIntyrePeter Simmonds
Nov 25, 2011·Journal of Virology·Toshiki Himeda, Yoshiro Ohara
Dec 14, 2011·Emerging Infectious Diseases·Jan Felix DrexlerChristian Drosten
Apr 4, 2012·Emerging Infectious Diseases·Andreas StöckerJan Felix Drexler
Jul 16, 2010·Reviews in Medical Virology·A N Lukashev
Jan 15, 2015·Journal of Medical Virology·Arpaporn YodmeeklinNiwat Maneekarn
Mar 2, 2012·The Journal of General Virology·Alexander N LukashevChristian Drosten
Jun 6, 2014·The Journal of General Virology·Asif NaeemHiroyuki Shimizu
Jul 28, 2010·The Journal of General Virology·Sanela SvrakaMarion Koopmans
Jan 11, 2011·The Journal of General Virology·Ilya S BelalovAlexander N Lukashev
Nov 28, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Pattara KhamrinHiroshi Ushijima
Oct 11, 2016·Reviews in Medical Virology·Shawn Zheng Kai TanMookkan Prabakaran
Jul 4, 2019·PloS One·Kira LindnerStephan Herberhold
Nov 16, 2019·Food and Environmental Virology·Mona AminipourNaser Harzandi

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