Genomic features of attenuated Junín virus vaccine strain candidate

Virus Genes
Sandra Elizabeth GoñiMario Enrique Lozano

Abstract

Junin virus strain Candid #1 was developed as a live attenuated vaccine for Argentine haemorrhagic fever. In this paper, we report the nucleotide sequences of L RNA of Candid #1 and examine the relationship to its more virulent ancestors Junin virus XJ#44 and XJ 13 (prototype) and other closely and distantly related arenaviruses. Comparisons of the nucleotide and amino acid sequences of L and Z genes of Candid #1 and its progenitor strains revealed twelve point mutations in the L polypeptide that are unique to the vaccine strain. These changes could be provisionally associated with the attenuated phenotype. In contrast, Z ORF was completely conserved among all strains.

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Citations

Feb 12, 2010·Virus Genes·Sandra Elizabeth GoñiMario Enrique Lozano
Jul 30, 2010·Journal of Virology·Jason BottenMichael J Buchmeier
Jul 25, 2009·Journal of Virology·Sudhakar S AgnihothramJack H Nunberg
Sep 2, 2011·Journal of Virology·Christian D CuevasSusan R Ross
Jul 24, 2010·Journal of Biomedicine & Biotechnology·S E GoñiM E Lozano
Jun 12, 2014·PloS One·Olga A KolokoltsovaSlobodan Paessler
May 23, 2012·Expert Opinion on Drug Discovery·Sheli R RadoshitzkySina Bavari
Oct 30, 2016·Journal of Virology·Lei-Ke ZhangGengfu Xiao
Jun 25, 2017·Annual Review of Virology·Nicolás Sarute, Susan R Ross
May 13, 2017·International Journal of Molecular Sciences·Hinh Ly
Mar 29, 2019·Frontiers in Immunology·Morgan E Brisse, Hinh Ly
Sep 26, 2020·PLoS Neglected Tropical Diseases·Steven J HallamSlobodan Paessler
Oct 13, 2020·PLoS Pathogens·Julia HolzerlandAllison Groseth

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Argentine Hemorrhagic Fever

Argentine hemorrhagic fever (AHF) is an endemo-epidemic disease caused by junín virus (JUNV), a member of the arenaviridae family. Discover the latest research on AHF here.